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Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis

Progranulin (PGRN) is a glycoprotein implicated in several neurodegenerative diseases. It is highly expressed in microglia and macrophages and can be secreted or delivered to the lysosome compartment. PGRN comprises 7.5 granulin repeats and is processed into individual granulin peptides within the l...

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Detalles Bibliográficos
Autores principales:	Santos, Mariela Nunez, Paushter, Daniel H., Zhang, Tingting, Wu, Xiaochun, Feng, Tuancheng, Lou, Jiaoying, Du, Huan, Becker, Stephanie M., Fragoza, Robert, Yu, Haiyuan, Hu, Fenghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450144/ https://www.ncbi.nlm.nih.gov/pubmed/35933009 http://dx.doi.org/10.1016/j.jbc.2022.102348

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