Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

BACKGROUND: A range of neurological pathologies may lead to secondary hydrocephalus. Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as specific and efficient pharmacological options are lacking, partly due to the elusive molecular nature of the CSF secretion appa...

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Detalles Bibliográficos
Autores principales: Toft-Bertelsen, Trine L., Barbuskaite, Dagne, Heerfordt, Eva Kjer, Lolansen, Sara Diana, Andreassen, Søren Norge, Rostgaard, Nina, Olsen, Markus Harboe, Norager, Nicolas H., Capion, Tenna, Rath, Martin Fredensborg, Juhler, Marianne, MacAulay, Nanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450297/
https://www.ncbi.nlm.nih.gov/pubmed/36068581
http://dx.doi.org/10.1186/s12987-022-00361-9

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