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An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics

BACKGROUND: HPV-related anal cancer occurs in excess rates among people living with HIV (PLWH) and has been increasing in incidence. The HPV vaccine is an effective and safe approach to prevent and reduce the risk of HPV-related disease. Yet, HPV vaccine programs tailored and implemented in the HIV...

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Autores principales: Wells, Jessica, Klosky, James L., Liu, Yuan, Gillespie, Theresa Wicklin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450352/
https://www.ncbi.nlm.nih.gov/pubmed/36071389
http://dx.doi.org/10.1186/s12889-022-14100-0
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author Wells, Jessica
Klosky, James L.
Liu, Yuan
Gillespie, Theresa Wicklin
author_facet Wells, Jessica
Klosky, James L.
Liu, Yuan
Gillespie, Theresa Wicklin
author_sort Wells, Jessica
collection PubMed
description BACKGROUND: HPV-related anal cancer occurs in excess rates among people living with HIV (PLWH) and has been increasing in incidence. The HPV vaccine is an effective and safe approach to prevent and reduce the risk of HPV-related disease. Yet, HPV vaccine programs tailored and implemented in the HIV population are lagging for this high-risk group. METHODS: A pre-post intervention study design will be used to tailor, refine, and implement the 4 Pillars™ Practice Transformation Program to increase HPV vaccination among PLWH. Guided by the RE-AIM framework, the CHAMPS study will provide training and motivation to HIV providers and clinic staff to recommend and administer the HPV vaccination within three HIV clinics in Georgia. We plan to enroll 365 HIV participants to receive HPV education, resources, and reminders for HPV vaccination. Sociodemographic, HPV knowledge, and vaccine hesitancy will be assessed as mediators and moderators for HPV vaccination. The primary outcome will be measured as an increase in uptake rate in initiation of the HPV vaccine and vaccine completion (secondary outcome) compared to historical baseline vaccination rate (control). DISCUSSION: The proposed study is a novel approach to address a serious and preventable public health problem by using an efficacious, evidence-based intervention on a new target population. The findings are anticipated to have a significant impact in the field of improving cancer outcomes in a high-risk and aging HIV population. TRIAL REGISTRATION: NCT05065840; October 4, 2021.
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spelling pubmed-94503522022-09-08 An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics Wells, Jessica Klosky, James L. Liu, Yuan Gillespie, Theresa Wicklin BMC Public Health Study Protocol BACKGROUND: HPV-related anal cancer occurs in excess rates among people living with HIV (PLWH) and has been increasing in incidence. The HPV vaccine is an effective and safe approach to prevent and reduce the risk of HPV-related disease. Yet, HPV vaccine programs tailored and implemented in the HIV population are lagging for this high-risk group. METHODS: A pre-post intervention study design will be used to tailor, refine, and implement the 4 Pillars™ Practice Transformation Program to increase HPV vaccination among PLWH. Guided by the RE-AIM framework, the CHAMPS study will provide training and motivation to HIV providers and clinic staff to recommend and administer the HPV vaccination within three HIV clinics in Georgia. We plan to enroll 365 HIV participants to receive HPV education, resources, and reminders for HPV vaccination. Sociodemographic, HPV knowledge, and vaccine hesitancy will be assessed as mediators and moderators for HPV vaccination. The primary outcome will be measured as an increase in uptake rate in initiation of the HPV vaccine and vaccine completion (secondary outcome) compared to historical baseline vaccination rate (control). DISCUSSION: The proposed study is a novel approach to address a serious and preventable public health problem by using an efficacious, evidence-based intervention on a new target population. The findings are anticipated to have a significant impact in the field of improving cancer outcomes in a high-risk and aging HIV population. TRIAL REGISTRATION: NCT05065840; October 4, 2021. BioMed Central 2022-09-07 /pmc/articles/PMC9450352/ /pubmed/36071389 http://dx.doi.org/10.1186/s12889-022-14100-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Study Protocol
Wells, Jessica
Klosky, James L.
Liu, Yuan
Gillespie, Theresa Wicklin
An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics
title An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics
title_full An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics
title_fullStr An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics
title_full_unstemmed An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics
title_short An overview of implementing an evidence based program to increase HPV vaccination in HIV community clinics
title_sort overview of implementing an evidence based program to increase hpv vaccination in hiv community clinics
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450352/
https://www.ncbi.nlm.nih.gov/pubmed/36071389
http://dx.doi.org/10.1186/s12889-022-14100-0
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