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Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast

BACKGROUND: To report a case of bilateral intermediate uveitis without cystoid macular edema secondary to paclitaxel therapy, and its successful management with oral corticosteroids. CASE PRESENTATION: A 66-year-old female developed bilateral intermediate uveitis with reduced best corrected visual a...

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Autores principales: Kvopka, Michael, Smith, Justine R., Koczwara, Bogda, Lake, Stewart R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450362/
https://www.ncbi.nlm.nih.gov/pubmed/36068624
http://dx.doi.org/10.1186/s40942-022-00415-y
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author Kvopka, Michael
Smith, Justine R.
Koczwara, Bogda
Lake, Stewart R.
author_facet Kvopka, Michael
Smith, Justine R.
Koczwara, Bogda
Lake, Stewart R.
author_sort Kvopka, Michael
collection PubMed
description BACKGROUND: To report a case of bilateral intermediate uveitis without cystoid macular edema secondary to paclitaxel therapy, and its successful management with oral corticosteroids. CASE PRESENTATION: A 66-year-old female developed bilateral intermediate uveitis with reduced best corrected visual acuity to 20/40 right and 20/200 left, following 12 cycles of paclitaxel therapy for breast carcinoma. Optical coherence tomography demonstrated no cystoid macular edema in either eye, and fundus fluorescein angiography showed localized retinal vascular leakage. Resolution of uveitis and improvement of visual acuity followed treatment with oral prednisolone for two months. Fourteen months after presentation, right and left visual acuities had returned to 20/32 and 20/40, respectively, and there was no recurrence of the uveitis. CONCLUSIONS: This is the first reported case of bilateral intermediate uveitis in a patient treated with paclitaxel. Drug-induced uveitis should be considered in patients with visual symptoms in the setting of taxane chemotherapy, and oral corticosteroids are a safe and effective treatment.
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spelling pubmed-94503622022-09-08 Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast Kvopka, Michael Smith, Justine R. Koczwara, Bogda Lake, Stewart R. Int J Retina Vitreous Case Report BACKGROUND: To report a case of bilateral intermediate uveitis without cystoid macular edema secondary to paclitaxel therapy, and its successful management with oral corticosteroids. CASE PRESENTATION: A 66-year-old female developed bilateral intermediate uveitis with reduced best corrected visual acuity to 20/40 right and 20/200 left, following 12 cycles of paclitaxel therapy for breast carcinoma. Optical coherence tomography demonstrated no cystoid macular edema in either eye, and fundus fluorescein angiography showed localized retinal vascular leakage. Resolution of uveitis and improvement of visual acuity followed treatment with oral prednisolone for two months. Fourteen months after presentation, right and left visual acuities had returned to 20/32 and 20/40, respectively, and there was no recurrence of the uveitis. CONCLUSIONS: This is the first reported case of bilateral intermediate uveitis in a patient treated with paclitaxel. Drug-induced uveitis should be considered in patients with visual symptoms in the setting of taxane chemotherapy, and oral corticosteroids are a safe and effective treatment. BioMed Central 2022-09-06 /pmc/articles/PMC9450362/ /pubmed/36068624 http://dx.doi.org/10.1186/s40942-022-00415-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Kvopka, Michael
Smith, Justine R.
Koczwara, Bogda
Lake, Stewart R.
Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast
title Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast
title_full Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast
title_fullStr Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast
title_full_unstemmed Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast
title_short Bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast
title_sort bilateral intermediate uveitis following treatment with paclitaxel in a patient with invasive ductal carcinoma of the breast
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450362/
https://www.ncbi.nlm.nih.gov/pubmed/36068624
http://dx.doi.org/10.1186/s40942-022-00415-y
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