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Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1

BACKGROUND: circRNA has been established to play a pivotal role in tumorigenesis development in a variety of cancers; nevertheless, the biological functions and molecular mechanisms of hypoxia-induced exosomal circRNAs in pancreatic cancer remain largely unknown. METHODS: Differentially expressed ci...

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Detalles Bibliográficos
Autores principales:	Lin, Jiewei, Wang, Xinjing, Zhai, Shuyu, Shi, Minmin, Peng, Chenghong, Deng, Xiaxing, Fu, Da, Wang, Jiancheng, Shen, Baiyong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450374/ https://www.ncbi.nlm.nih.gov/pubmed/36068586 http://dx.doi.org/10.1186/s13045-022-01348-7

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