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Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

BACKGROUND: Targeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal proteins, RPL11 centralizes the nucleolar stress-sensing pathway by binding MDM2, leading to MDM2 inactivation and p53 activation. Therefore, the identifi...

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Detalles Bibliográficos
Autores principales:	Wang, Bingwu, Gao, Jian, Zhao, Zhongjun, Zhong, Xuefei, Cui, Hao, Hou, Hui, Zhang, Yanping, Zheng, Junnian, Di, Jiehui, Liu, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450376/ https://www.ncbi.nlm.nih.gov/pubmed/36071402 http://dx.doi.org/10.1186/s10020-022-00537-x

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