Cargando…

A computational evaluation of structural stability of omicron and delta mutations of SARS-CoV-2 spike proteins and human ACE-2 interactions

Several more infectious SARS-CoV-2 variants have emerged globally since SARS-CoV-2 pandemic and the discovery of the first D614G variant of SARS-CoV-2 spike proteins in 2020. Delta (B.1.617.2) and Omicron (B.1.1.529) variants have proven to be of major concern out of all the reported variants, consi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Idowu, Kehinde A., Onyenaka, Collins, Olaleye, Omonike A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. Published by Elsevier Ltd. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450468/ https://www.ncbi.nlm.nih.gov/pubmed/36092780 http://dx.doi.org/10.1016/j.imu.2022.101074

Ejemplares similares

Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro
por: Olaleye, Omonike A., et al.
Publicado: (2021)

Inhibitory mechanism of Ambroxol and Bromhexine Hydrochlorides as potent blockers of molecular interaction between SARS-CoV-2 spike protein and human angiotensin-converting Enzyme-2
por: Kehinde, Idowu A., et al.
Publicado: (2022)

Effect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface Complex
por: Ching, Wai-Yim, et al.
Publicado: (2022)

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
por: Han, Pengcheng, et al.
Publicado: (2022)

The Global Alliance for Maternal and Child Health (GLAM): A Pioneer Organization for MCH Students
por: Harris, Kiydra, et al.
Publicado: (2021)

Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody
por: Yin, Wanchao, et al.
Publicado: (2022)

SARS-CoV-2 Omicron Mutation Is Faster than the Chase: Multiple Mutations on Spike/ACE2 Interaction Residues
por: Kim, Sinae, et al.
Publicado: (2021)

Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants
por: da Costa, Clauber Henrique Souza, et al.
Publicado: (2022)

ACE2-Targeting antibody suppresses SARS-CoV-2 Omicron and Delta variants
por: Ou, Jianxia, et al.
Publicado: (2022)

Deciphering the Impact of Mutations on the Binding Efficacy of SARS-CoV-2 Omicron and Delta Variants With Human ACE2 Receptor
por: Khan, Alamgir, et al.
Publicado: (2022)

Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike – ACE2 complexes reveal distinct changes between both variants
por: Socher, Eileen, et al.
Publicado: (2022)

SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope
por: He, Ping, et al.
Publicado: (2022)

Distinct Conformations of SARS-CoV-2 Omicron Spike Protein and Its Interaction with ACE2 and Antibody
por: Lee, Myeongsang, et al.
Publicado: (2023)

Molecular and computational analysis of spike protein of newly emerged omicron variant in comparison to the delta variant of SARS-CoV-2 in Iraq
por: Rashid, Peshnyar M. A., et al.
Publicado: (2022)

Comparative Computational Analysis of Spike Protein Structural Stability in SARS-CoV-2 Omicron Subvariants
por: Balupuri, Anand, et al.
Publicado: (2023)

Interaction Analysis of the Spike Protein of Delta and Omicron Variants of SARS-CoV-2 with hACE2 and Eight Monoclonal Antibodies Using the Fragment Molecular Orbital Method
por: Hwang, Sungbo, et al.
Publicado: (2022)

Molecular dynamics simulations highlight the altered binding landscape at the spike-ACE2 interface between the Delta and Omicron variants compared to the SARS-CoV-2 original strain
por: Pitsillou, Eleni, et al.
Publicado: (2022)

Cheminformatics Bioprospection of Broad Spectrum Plant Secondary Metabolites Targeting the Spike Proteins of Omicron Variant and Wild-Type SARS-CoV-2
por: Aribisala, Jamiu Olaseni, et al.
Publicado: (2022)

The SARS-CoV-2 Delta (B.1.617.2) variant with spike N501Y mutation in the shadow of Omicron emergence
por: Salimović-Bešić, Irma, et al.
Publicado: (2022)

Analyzing the interaction of human ACE2 and RBD of spike protein of SARS-CoV-2 in perspective of Omicron variant
por: Samanta, Arijit, et al.
Publicado: (2022)

Temperature Influences the Interaction between SARS-CoV-2 Spike from Omicron Subvariants and Human ACE2
por: Gong, Shang Yu, et al.
Publicado: (2022)

Omicron BA.1 and BA.2 variants increase the interactions of SARS-CoV-2 spike glycoprotein with ACE2
por: Golcuk, Mert, et al.
Publicado: (2022)

Missense mutations in spike protein of SARS‐CoV‐2 delta variant contribute to the alteration in viral structure and interaction with hACE2 receptor
por: Mahmood, Tousif Bin, et al.
Publicado: (2022)

Structural and functional impact by SARS-CoV-2 Omicron spike mutations
por: Zhang, Jun, et al.
Publicado: (2022)

Electrostatic Interactions Are the Primary Determinant of the Binding Affinity of SARS-CoV-2 Spike RBD to ACE2: A Computational Case Study of Omicron Variants
por: Sang, Peng, et al.
Publicado: (2022)

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
por: Mannar, Dhiraj, et al.
Publicado: (2022)

SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage
por: Jawaid, M. Zaki, et al.
Publicado: (2023)

SARS-CoV-2 pan-variant inhibitory peptides deter S1-ACE2 interaction and neutralize delta and omicron pseudoviruses
por: Shah, Masaud, et al.
Publicado: (2022)

Stability of SARS-CoV-2 variants of concern (Delta and Omicron) on surfaces at room temperature
por: Pottage, Thomas, et al.
Publicado: (2023)

SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptors
por: Mishra, Pushpendra Mani, et al.
Publicado: (2022)

Molecular dynamic simulation suggests stronger interaction of Omicron-spike with ACE2 than wild but weaker than Delta SARS-CoV-2 can be blocked by engineered S1-RBD fraction
por: Santra, Dipannita, et al.
Publicado: (2022)

Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding
por: Thakur, Shivani, et al.
Publicado: (2023)

Omicron SARS-CoV-2 Variant Spike Protein Shows an Increased Affinity to the Human ACE2 Receptor: An In Silico Analysis
por: Ortega, Joseph Thomas, et al.
Publicado: (2021)

Computer Simulations and Network-Based Profiling of Binding and Allosteric Interactions of SARS-CoV-2 Spike Variant Complexes and the Host Receptor: Dissecting the Mechanistic Effects of the Delta and Omicron Mutations
por: Verkhivker, Gennady, et al.
Publicado: (2022)

The Quantification of Spike Proteins in the Inactivated SARS-CoV-2 Vaccines of the Prototype, Delta, and Omicron Variants by LC–MS
por: Xu, Kangwei, et al.
Publicado: (2023)

In silico identification of deep-sea fungal alkaloids as potential inhibitors of SARS-CoV-2, Delta and Omicron spikes
por: Alanzi, Abdullah R, et al.
Publicado: (2023)

Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo
por: Li, Mengjiao, et al.
Publicado: (2022)

SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2
por: Wu, Leyun, et al.
Publicado: (2022)

Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice
por: Tarrés-Freixas, Ferran, et al.
Publicado: (2022)

Structural Evolution of Delta (B.1.617.2) and Omicron (BA.1) Spike Glycoproteins
por: Prandi, Ingrid Guarnetti, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_16v2nh7a5e5hkka1pdm0ivjlv9