The molecular mechanisms of ferroptosis and its role in glioma progression and treatment

Ferroptosis is one of the programmed modes of cell death that has attracted widespread attention recently and is capable of influencing the developmental course and prognosis of many tumors. Glioma is one of the most common primary tumors of the central nervous system, but effective treatment option...

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Autores principales: Lu, Mengyang, Zhou, Yuanshuai, Sun, Linjuan, Shafi, Shaheryar, Ahmad, Nafees, Sun, Minxuan, Dong, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450584/
https://www.ncbi.nlm.nih.gov/pubmed/36091118
http://dx.doi.org/10.3389/fonc.2022.917537
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author Lu, Mengyang
Zhou, Yuanshuai
Sun, Linjuan
Shafi, Shaheryar
Ahmad, Nafees
Sun, Minxuan
Dong, Jun
author_facet Lu, Mengyang
Zhou, Yuanshuai
Sun, Linjuan
Shafi, Shaheryar
Ahmad, Nafees
Sun, Minxuan
Dong, Jun
author_sort Lu, Mengyang
collection PubMed
description Ferroptosis is one of the programmed modes of cell death that has attracted widespread attention recently and is capable of influencing the developmental course and prognosis of many tumors. Glioma is one of the most common primary tumors of the central nervous system, but effective treatment options are very limited. Ferroptosis plays a critical role in the glioma progression, affecting tumor cell proliferation, angiogenesis, tumor necrosis, and shaping the immune-resistant tumor microenvironment. Inducing ferroptosis has emerged as an attractive strategy for glioma. In this paper, we review ferroptosis-related researches on glioma progression and treatment.
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spelling pubmed-94505842022-09-08 The molecular mechanisms of ferroptosis and its role in glioma progression and treatment Lu, Mengyang Zhou, Yuanshuai Sun, Linjuan Shafi, Shaheryar Ahmad, Nafees Sun, Minxuan Dong, Jun Front Oncol Oncology Ferroptosis is one of the programmed modes of cell death that has attracted widespread attention recently and is capable of influencing the developmental course and prognosis of many tumors. Glioma is one of the most common primary tumors of the central nervous system, but effective treatment options are very limited. Ferroptosis plays a critical role in the glioma progression, affecting tumor cell proliferation, angiogenesis, tumor necrosis, and shaping the immune-resistant tumor microenvironment. Inducing ferroptosis has emerged as an attractive strategy for glioma. In this paper, we review ferroptosis-related researches on glioma progression and treatment. Frontiers Media S.A. 2022-08-16 /pmc/articles/PMC9450584/ /pubmed/36091118 http://dx.doi.org/10.3389/fonc.2022.917537 Text en Copyright © 2022 Lu, Zhou, Sun, Shafi, Ahmad, Sun and Dong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lu, Mengyang
Zhou, Yuanshuai
Sun, Linjuan
Shafi, Shaheryar
Ahmad, Nafees
Sun, Minxuan
Dong, Jun
The molecular mechanisms of ferroptosis and its role in glioma progression and treatment
title The molecular mechanisms of ferroptosis and its role in glioma progression and treatment
title_full The molecular mechanisms of ferroptosis and its role in glioma progression and treatment
title_fullStr The molecular mechanisms of ferroptosis and its role in glioma progression and treatment
title_full_unstemmed The molecular mechanisms of ferroptosis and its role in glioma progression and treatment
title_short The molecular mechanisms of ferroptosis and its role in glioma progression and treatment
title_sort molecular mechanisms of ferroptosis and its role in glioma progression and treatment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450584/
https://www.ncbi.nlm.nih.gov/pubmed/36091118
http://dx.doi.org/10.3389/fonc.2022.917537
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