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Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone different molecular changes, sprouting genetic variants of the original wildtype. Clinical comparisons between patients infected with alpha versus delta are scarce. METHODS: In this retrospective observational stu...

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Autores principales: Rumpf, Benedikt, Lickefett, Benno, Baumgartner, Clemens, Kauer, Victoria, Karolyi, Mario, Pawelka, Erich, Seitz, Tamara, Traugott, Marianna, Triska, Petr, Bergthaler, Andreas, Laferl, Hermann, Wenisch, Christoph, Zoufaly, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450815/
https://www.ncbi.nlm.nih.gov/pubmed/36070027
http://dx.doi.org/10.1007/s00508-022-02084-1
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author Rumpf, Benedikt
Lickefett, Benno
Baumgartner, Clemens
Kauer, Victoria
Karolyi, Mario
Pawelka, Erich
Seitz, Tamara
Traugott, Marianna
Triska, Petr
Bergthaler, Andreas
Laferl, Hermann
Wenisch, Christoph
Zoufaly, Alexander
author_facet Rumpf, Benedikt
Lickefett, Benno
Baumgartner, Clemens
Kauer, Victoria
Karolyi, Mario
Pawelka, Erich
Seitz, Tamara
Traugott, Marianna
Triska, Petr
Bergthaler, Andreas
Laferl, Hermann
Wenisch, Christoph
Zoufaly, Alexander
author_sort Rumpf, Benedikt
collection PubMed
description BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone different molecular changes, sprouting genetic variants of the original wildtype. Clinical comparisons between patients infected with alpha versus delta are scarce. METHODS: In this retrospective observational study, adult patients hospitalized with coronavirus disease 2019 (COVID-19) due to confirmed SARS-CoV‑2 alpha or delta infection were included. Patient characteristics, virologic and laboratory parameters, as well as the clinical course were compared in patients infected with alpha vs. delta variants. RESULTS: A total of 106 patients infected with alpha and 215 patients infected with delta were included. Patients infected with the delta variant were admitted to hospital earlier after symptom onset (6 vs. 7 days, p < 0.001). Blood levels of C‑reactive protein (43.3 vs. 62.9 mg/l, p = 0.02) and neutrophil count (3.81 vs. 4.53 G/l, p = 0.06) were lower in delta patients. Furthermore, at hospital admission cycle threshold (CT) values were significantly lower in patients infected with the delta variant (22.3 vs. 24.9, p < 0.001). Patients infected with the delta variant needed supplemental oxygen less often during disease course (50% vs. 64%, p = 0.02). Furthermore, there was a statistically non-significant trend towards a lower ICU admission rate among delta patients (16% vs. 24%, p = 0.08) CONCLUSION: Patients diagnosed with the delta variant were admitted to the hospital earlier, had a less severe course of disease and a higher viral replication on admission. This may provide a window of opportunity for antivirals in the hospital setting.
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spelling pubmed-94508152022-09-07 Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants Rumpf, Benedikt Lickefett, Benno Baumgartner, Clemens Kauer, Victoria Karolyi, Mario Pawelka, Erich Seitz, Tamara Traugott, Marianna Triska, Petr Bergthaler, Andreas Laferl, Hermann Wenisch, Christoph Zoufaly, Alexander Wien Klin Wochenschr Original Article BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone different molecular changes, sprouting genetic variants of the original wildtype. Clinical comparisons between patients infected with alpha versus delta are scarce. METHODS: In this retrospective observational study, adult patients hospitalized with coronavirus disease 2019 (COVID-19) due to confirmed SARS-CoV‑2 alpha or delta infection were included. Patient characteristics, virologic and laboratory parameters, as well as the clinical course were compared in patients infected with alpha vs. delta variants. RESULTS: A total of 106 patients infected with alpha and 215 patients infected with delta were included. Patients infected with the delta variant were admitted to hospital earlier after symptom onset (6 vs. 7 days, p < 0.001). Blood levels of C‑reactive protein (43.3 vs. 62.9 mg/l, p = 0.02) and neutrophil count (3.81 vs. 4.53 G/l, p = 0.06) were lower in delta patients. Furthermore, at hospital admission cycle threshold (CT) values were significantly lower in patients infected with the delta variant (22.3 vs. 24.9, p < 0.001). Patients infected with the delta variant needed supplemental oxygen less often during disease course (50% vs. 64%, p = 0.02). Furthermore, there was a statistically non-significant trend towards a lower ICU admission rate among delta patients (16% vs. 24%, p = 0.08) CONCLUSION: Patients diagnosed with the delta variant were admitted to the hospital earlier, had a less severe course of disease and a higher viral replication on admission. This may provide a window of opportunity for antivirals in the hospital setting. Springer Vienna 2022-09-07 2022 /pmc/articles/PMC9450815/ /pubmed/36070027 http://dx.doi.org/10.1007/s00508-022-02084-1 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Rumpf, Benedikt
Lickefett, Benno
Baumgartner, Clemens
Kauer, Victoria
Karolyi, Mario
Pawelka, Erich
Seitz, Tamara
Traugott, Marianna
Triska, Petr
Bergthaler, Andreas
Laferl, Hermann
Wenisch, Christoph
Zoufaly, Alexander
Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
title Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
title_full Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
title_fullStr Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
title_full_unstemmed Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
title_short Comparison of clinical characteristics among patients infected with alpha vs. delta SARS-CoV-2 variants
title_sort comparison of clinical characteristics among patients infected with alpha vs. delta sars-cov-2 variants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450815/
https://www.ncbi.nlm.nih.gov/pubmed/36070027
http://dx.doi.org/10.1007/s00508-022-02084-1
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