Human arginase 1, a Jack of all trades?

Arginine, a conditionally essential amino acid, plays a crucial role in several metabolic and signalling pathways. Arginine metabolism in the body can be significantly increased under stress or during certain pathological conditions. Depletion of circulating arginine by administering arginine-hydrol...

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Autores principales: Anakha, J., Kawathe, Priyanka S., Datta, Sayantap, Jawalekar, Snehal Sainath, Banerjee, Uttam Chand, Pande, Abhay H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450830/
https://www.ncbi.nlm.nih.gov/pubmed/36082360
http://dx.doi.org/10.1007/s13205-022-03326-9
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author Anakha, J.
Kawathe, Priyanka S.
Datta, Sayantap
Jawalekar, Snehal Sainath
Banerjee, Uttam Chand
Pande, Abhay H.
author_facet Anakha, J.
Kawathe, Priyanka S.
Datta, Sayantap
Jawalekar, Snehal Sainath
Banerjee, Uttam Chand
Pande, Abhay H.
author_sort Anakha, J.
collection PubMed
description Arginine, a conditionally essential amino acid, plays a crucial role in several metabolic and signalling pathways. Arginine metabolism in the body can be significantly increased under stress or during certain pathological conditions. Depletion of circulating arginine by administering arginine-hydrolysing enzyme has been shown to mitigate varied pathophysiological conditions ranging from cancer, inflammatory conditions, and microbial infection. This review provides an overview of such intriguing expanse of potential applications of recombinant human arginase 1 for different pathological conditions and its status of development.
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spelling pubmed-94508302022-09-07 Human arginase 1, a Jack of all trades? Anakha, J. Kawathe, Priyanka S. Datta, Sayantap Jawalekar, Snehal Sainath Banerjee, Uttam Chand Pande, Abhay H. 3 Biotech Review Article Arginine, a conditionally essential amino acid, plays a crucial role in several metabolic and signalling pathways. Arginine metabolism in the body can be significantly increased under stress or during certain pathological conditions. Depletion of circulating arginine by administering arginine-hydrolysing enzyme has been shown to mitigate varied pathophysiological conditions ranging from cancer, inflammatory conditions, and microbial infection. This review provides an overview of such intriguing expanse of potential applications of recombinant human arginase 1 for different pathological conditions and its status of development. Springer International Publishing 2022-09-07 2022-10 /pmc/articles/PMC9450830/ /pubmed/36082360 http://dx.doi.org/10.1007/s13205-022-03326-9 Text en © King Abdulaziz City for Science and Technology 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
spellingShingle Review Article
Anakha, J.
Kawathe, Priyanka S.
Datta, Sayantap
Jawalekar, Snehal Sainath
Banerjee, Uttam Chand
Pande, Abhay H.
Human arginase 1, a Jack of all trades?
title Human arginase 1, a Jack of all trades?
title_full Human arginase 1, a Jack of all trades?
title_fullStr Human arginase 1, a Jack of all trades?
title_full_unstemmed Human arginase 1, a Jack of all trades?
title_short Human arginase 1, a Jack of all trades?
title_sort human arginase 1, a jack of all trades?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450830/
https://www.ncbi.nlm.nih.gov/pubmed/36082360
http://dx.doi.org/10.1007/s13205-022-03326-9
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