Indications and pitfalls of immunohistochemistry in head and neck cancer

Immunohistochemistry (IHC) has been employed in the differential diagnosis of tumors. OBJECTIVE: To assess the use of IHC in cases of head and neck tumor. METHOD: This is a retrospective study of the cases included in the Cancer Registry of the institution. RESULTS: IHC was used in 76 (11%) of 704 p...

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Autores principales: Caly, Décio de Natale, Viana, Acklei, Rapoport, Abrão, Dedivitis, Rogério Aparecido, Curioni, Otávio Alberto, Cernea, Cláudio Roberto, Brandão, Lenine Garcia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450862/
https://www.ncbi.nlm.nih.gov/pubmed/23503911
http://dx.doi.org/10.5935/1808-8694.20130013
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author Caly, Décio de Natale
Viana, Acklei
Rapoport, Abrão
Dedivitis, Rogério Aparecido
Curioni, Otávio Alberto
Cernea, Cláudio Roberto
Brandão, Lenine Garcia
author_facet Caly, Décio de Natale
Viana, Acklei
Rapoport, Abrão
Dedivitis, Rogério Aparecido
Curioni, Otávio Alberto
Cernea, Cláudio Roberto
Brandão, Lenine Garcia
author_sort Caly, Décio de Natale
collection PubMed
description Immunohistochemistry (IHC) has been employed in the differential diagnosis of tumors. OBJECTIVE: To assess the use of IHC in cases of head and neck tumor. METHOD: This is a retrospective study of the cases included in the Cancer Registry of the institution. RESULTS: IHC was used in 76 (11%) of 704 pathology tests. Most cases were carcinomas (85.80%), and 83.66% of them were squamous cell carcinomas. All tests were done with diagnostic purposes. The most frequently used antibodies were 34BE12 (37.18%), AE1/AE3 (35.9%), 35BH11 (28.21%), CD45 (25.64%), CD20 (24.36%), CD30 (24.36%), CK7 (23.08%) and CD3 (23.08%). CONCLUSIONS: IHC was used in 10.67% of the head and neck tumor cases submitted to pathology testing, mostly for carcinoma (5.26%). In the determination of squamous cell carcinoma, IHC accounted for 18.42% of all tumors.
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spelling pubmed-94508622022-09-09 Indications and pitfalls of immunohistochemistry in head and neck cancer Caly, Décio de Natale Viana, Acklei Rapoport, Abrão Dedivitis, Rogério Aparecido Curioni, Otávio Alberto Cernea, Cláudio Roberto Brandão, Lenine Garcia Braz J Otorhinolaryngol Original Article Immunohistochemistry (IHC) has been employed in the differential diagnosis of tumors. OBJECTIVE: To assess the use of IHC in cases of head and neck tumor. METHOD: This is a retrospective study of the cases included in the Cancer Registry of the institution. RESULTS: IHC was used in 76 (11%) of 704 pathology tests. Most cases were carcinomas (85.80%), and 83.66% of them were squamous cell carcinomas. All tests were done with diagnostic purposes. The most frequently used antibodies were 34BE12 (37.18%), AE1/AE3 (35.9%), 35BH11 (28.21%), CD45 (25.64%), CD20 (24.36%), CD30 (24.36%), CK7 (23.08%) and CD3 (23.08%). CONCLUSIONS: IHC was used in 10.67% of the head and neck tumor cases submitted to pathology testing, mostly for carcinoma (5.26%). In the determination of squamous cell carcinoma, IHC accounted for 18.42% of all tumors. Elsevier 2015-10-14 /pmc/articles/PMC9450862/ /pubmed/23503911 http://dx.doi.org/10.5935/1808-8694.20130013 Text en . https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Caly, Décio de Natale
Viana, Acklei
Rapoport, Abrão
Dedivitis, Rogério Aparecido
Curioni, Otávio Alberto
Cernea, Cláudio Roberto
Brandão, Lenine Garcia
Indications and pitfalls of immunohistochemistry in head and neck cancer
title Indications and pitfalls of immunohistochemistry in head and neck cancer
title_full Indications and pitfalls of immunohistochemistry in head and neck cancer
title_fullStr Indications and pitfalls of immunohistochemistry in head and neck cancer
title_full_unstemmed Indications and pitfalls of immunohistochemistry in head and neck cancer
title_short Indications and pitfalls of immunohistochemistry in head and neck cancer
title_sort indications and pitfalls of immunohistochemistry in head and neck cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450862/
https://www.ncbi.nlm.nih.gov/pubmed/23503911
http://dx.doi.org/10.5935/1808-8694.20130013
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