CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy

Resistance remains an obstacle to anti-programmed cell death protein 1 (PD-1) therapy in human cancer. One critical resistance mechanism is the lack of T cell chemotaxis in the tumor microenvironment (TME). CXCL10-CXCR3 signaling is required for T cell tumor infiltration and tumor immunotherapy. Onc...

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Detalles Bibliográficos
Autores principales: Li, Xiaofei, Lu, Mingjie, Yuan, Manman, Ye, Jing, Zhang, Wei, Xu, Lingyan, Wu, Xiaohan, Hui, Bingqing, Yang, Yuchen, Wei, Bin, Guo, Ciliang, Wei, Min, Dong, Jie, Wu, Xingxin, Gu, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450898/
https://www.ncbi.nlm.nih.gov/pubmed/36092638
http://dx.doi.org/10.1080/2162402X.2022.2118210

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