CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Mitophagy is a type of selective macroautophagy/autophagy that degrades dysfunctional or excessive mitochondria. Regulation of this process is critical for maintaining cellular homeostasis and has been closely implicated in acquired drug resistance. However, the regulatory mechanisms and influences...

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Detalles Bibliográficos
Autores principales: Yao, Jingyue, Wang, Jubo, Xu, Ye, Guo, Qinglong, Sun, Yuening, Liu, Jian, Li, Sichan, Guo, Yongjian, Wei, Libin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450969/
https://www.ncbi.nlm.nih.gov/pubmed/34890308
http://dx.doi.org/10.1080/15548627.2021.2007027

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