ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer

Hypoxia is a common feature of solid tumors and is associated with increased tumor progression, resistance to therapy and increased metastasis. Hence, tumor hypoxia is a prognostic factor independent of treatment modality. To survive hypoxia, cells activate macroautophagy/autophagy. Paradoxically, i...

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Detalles Bibliográficos
Autores principales: Keulers, Tom G., Koch, Alexander, van Gisbergen, Marike W., Barbeau, Lydie M.O., Zonneveld, Marijke I., de Jong, Monique C., Savelkouls, Kim G.M., Wanders, Roel G., Bussink, Johan, Melotte, Veerle, Rouschop, Kasper M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450974/
https://www.ncbi.nlm.nih.gov/pubmed/34904929
http://dx.doi.org/10.1080/15548627.2021.2008690

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