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Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation

Chronic lower respiratory tract infections are a leading contributor to morbidity and mortality in persons with cystic fibrosis (pwCF). Traditional respiratory tract surveillance culturing has focused on a limited range of classic pathogens; however, comprehensive culture and culture-independent mol...

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Detalles Bibliográficos
Autores principales: Thornton, Christina S, Acosta, Nicole, Surette, Michael G, Parkins, Michael D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451016/
https://www.ncbi.nlm.nih.gov/pubmed/36069903
http://dx.doi.org/10.1093/jpids/piac036
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author Thornton, Christina S
Acosta, Nicole
Surette, Michael G
Parkins, Michael D
author_facet Thornton, Christina S
Acosta, Nicole
Surette, Michael G
Parkins, Michael D
author_sort Thornton, Christina S
collection PubMed
description Chronic lower respiratory tract infections are a leading contributor to morbidity and mortality in persons with cystic fibrosis (pwCF). Traditional respiratory tract surveillance culturing has focused on a limited range of classic pathogens; however, comprehensive culture and culture-independent molecular approaches have demonstrated complex communities highly unique to each individual. Microbial community structure evolves through the lifetime of pwCF and is associated with baseline disease state and rates of disease progression including occurrence of pulmonary exacerbations. While molecular analysis of the airway microbiome has provided insight into these dynamics, challenges remain including discerning not only “who is there” but “what they are doing” in relation to disease progression. Moreover, the microbiome can be leveraged as a multi-modal biomarker for both disease activity and prognostication. In this article, we review our evolving understanding of the role these communities play in pwCF and identify challenges in translating microbiome data to clinical practice.
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spelling pubmed-94510162022-09-08 Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation Thornton, Christina S Acosta, Nicole Surette, Michael G Parkins, Michael D J Pediatric Infect Dis Soc Supplement Articles Chronic lower respiratory tract infections are a leading contributor to morbidity and mortality in persons with cystic fibrosis (pwCF). Traditional respiratory tract surveillance culturing has focused on a limited range of classic pathogens; however, comprehensive culture and culture-independent molecular approaches have demonstrated complex communities highly unique to each individual. Microbial community structure evolves through the lifetime of pwCF and is associated with baseline disease state and rates of disease progression including occurrence of pulmonary exacerbations. While molecular analysis of the airway microbiome has provided insight into these dynamics, challenges remain including discerning not only “who is there” but “what they are doing” in relation to disease progression. Moreover, the microbiome can be leveraged as a multi-modal biomarker for both disease activity and prognostication. In this article, we review our evolving understanding of the role these communities play in pwCF and identify challenges in translating microbiome data to clinical practice. Oxford University Press 2022-09-07 /pmc/articles/PMC9451016/ /pubmed/36069903 http://dx.doi.org/10.1093/jpids/piac036 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Articles
Thornton, Christina S
Acosta, Nicole
Surette, Michael G
Parkins, Michael D
Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
title Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
title_full Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
title_fullStr Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
title_full_unstemmed Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
title_short Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
title_sort exploring the cystic fibrosis lung microbiome: making the most of a sticky situation
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451016/
https://www.ncbi.nlm.nih.gov/pubmed/36069903
http://dx.doi.org/10.1093/jpids/piac036
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