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Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review

Leakage of the anastomotic site is considered to be one of the most serious complications after colon and rectal surgery. It is associated with increased mortality, morbidity, and longer hospital stays. This systematic review examines the need for blood markers such as C-reactive protein (CRP), proc...

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Autores principales: Selvamani, Tharun Yadhav, Shoukrie, Shoukrie I, Malla, Jyothirmai, Venugopal, Sathish, Selvaraj, Ramaneshwar, Dhanoa, Ravneet K, Zahra, Anam, Hamouda, Ranim K, Raman, Aishwarya, Mostafa, Jihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451042/
https://www.ncbi.nlm.nih.gov/pubmed/36105895
http://dx.doi.org/10.7759/cureus.28894
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author Selvamani, Tharun Yadhav
Shoukrie, Shoukrie I
Malla, Jyothirmai
Venugopal, Sathish
Selvaraj, Ramaneshwar
Dhanoa, Ravneet K
Zahra, Anam
Hamouda, Ranim K
Raman, Aishwarya
Mostafa, Jihan
author_facet Selvamani, Tharun Yadhav
Shoukrie, Shoukrie I
Malla, Jyothirmai
Venugopal, Sathish
Selvaraj, Ramaneshwar
Dhanoa, Ravneet K
Zahra, Anam
Hamouda, Ranim K
Raman, Aishwarya
Mostafa, Jihan
author_sort Selvamani, Tharun Yadhav
collection PubMed
description Leakage of the anastomotic site is considered to be one of the most serious complications after colon and rectal surgery. It is associated with increased mortality, morbidity, and longer hospital stays. This systematic review examines the need for blood markers such as C-reactive protein (CRP), procalcitonin (PCT), albumin, and various other molecular markers that assist in their propensity to diagnose anastomotic leakage (AL) early after surgery. Utilizing PubMed and Google Scholar as resources and including the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for the articles, and studies over the last five years were included. A total of 12 studies have been discussed, and most articles suggest CRP as an excellent indicator. CRP compared to Dutch leakage scores (DLS) and PCT studies suggest that the three combinations improve the predictable outcome of AL. In addition, CRP and PCT have been shown to diagnose AL early in the postoperative period. Other studies include the role of markers of oxidative stress markers, Interleukin-6, Interleukin-10, and other molecular markers in the peritoneal drain which are predictive for identifying AL after three days postoperatively (POD-3). Overall, CRP has proven to be a reliable standard indicator of diagnosis. This is because the postoperative elevation of this protein indicates a problem of leakage with clinical symptoms. Other blood parameters are useful for diagnosis as well, but the limitations are the lack of appropriate studies and the number of randomized controlled trials in this area of ​​study.
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spelling pubmed-94510422022-09-13 Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review Selvamani, Tharun Yadhav Shoukrie, Shoukrie I Malla, Jyothirmai Venugopal, Sathish Selvaraj, Ramaneshwar Dhanoa, Ravneet K Zahra, Anam Hamouda, Ranim K Raman, Aishwarya Mostafa, Jihan Cureus Emergency Medicine Leakage of the anastomotic site is considered to be one of the most serious complications after colon and rectal surgery. It is associated with increased mortality, morbidity, and longer hospital stays. This systematic review examines the need for blood markers such as C-reactive protein (CRP), procalcitonin (PCT), albumin, and various other molecular markers that assist in their propensity to diagnose anastomotic leakage (AL) early after surgery. Utilizing PubMed and Google Scholar as resources and including the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for the articles, and studies over the last five years were included. A total of 12 studies have been discussed, and most articles suggest CRP as an excellent indicator. CRP compared to Dutch leakage scores (DLS) and PCT studies suggest that the three combinations improve the predictable outcome of AL. In addition, CRP and PCT have been shown to diagnose AL early in the postoperative period. Other studies include the role of markers of oxidative stress markers, Interleukin-6, Interleukin-10, and other molecular markers in the peritoneal drain which are predictive for identifying AL after three days postoperatively (POD-3). Overall, CRP has proven to be a reliable standard indicator of diagnosis. This is because the postoperative elevation of this protein indicates a problem of leakage with clinical symptoms. Other blood parameters are useful for diagnosis as well, but the limitations are the lack of appropriate studies and the number of randomized controlled trials in this area of ​​study. Cureus 2022-09-07 /pmc/articles/PMC9451042/ /pubmed/36105895 http://dx.doi.org/10.7759/cureus.28894 Text en Copyright © 2022, Selvamani et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Selvamani, Tharun Yadhav
Shoukrie, Shoukrie I
Malla, Jyothirmai
Venugopal, Sathish
Selvaraj, Ramaneshwar
Dhanoa, Ravneet K
Zahra, Anam
Hamouda, Ranim K
Raman, Aishwarya
Mostafa, Jihan
Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review
title Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review
title_full Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review
title_fullStr Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review
title_full_unstemmed Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review
title_short Predictors That Identify Complications Such As Anastomotic Leak in Colorectal Surgery: A Systematic Review
title_sort predictors that identify complications such as anastomotic leak in colorectal surgery: a systematic review
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451042/
https://www.ncbi.nlm.nih.gov/pubmed/36105895
http://dx.doi.org/10.7759/cureus.28894
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