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Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?

Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria. Among the proposed hypotheses that seek to explain the manifestation of the neurological syndrome in cerebral malaria is the vascular o...

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Autores principales: Daniyan, Michael Oluwatoyin, Fisusi, Funmilola Adesodun, Adeoye, Olufunso Bayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451049/
https://www.ncbi.nlm.nih.gov/pubmed/36090033
http://dx.doi.org/10.3389/fmolb.2022.965569
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author Daniyan, Michael Oluwatoyin
Fisusi, Funmilola Adesodun
Adeoye, Olufunso Bayo
author_facet Daniyan, Michael Oluwatoyin
Fisusi, Funmilola Adesodun
Adeoye, Olufunso Bayo
author_sort Daniyan, Michael Oluwatoyin
collection PubMed
description Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria. Among the proposed hypotheses that seek to explain the manifestation of the neurological syndrome in cerebral malaria is the vascular occlusion/sequestration/mechanic hypothesis, the cytokine storm or inflammatory theory, or a combination of both. Unfortunately, despite the increasing volume of scientific information on cerebral malaria, our understanding of its pathophysiologic mechanism(s) is still very limited. In a bid to maintain its survival and development, P. falciparum exports a large number of proteins into the cytosol of the infected host red blood cell. Prominent among these are the P. falciparum erythrocytes membrane protein 1 (PfEMP1), P. falciparum histidine-rich protein II (PfHRP2), and P. falciparum heat shock proteins 70-x (PfHsp70-x). Functional activities and interaction of these proteins with one another and with recruited host resident proteins are critical factors in the pathology of malaria in general and cerebral malaria in particular. Furthermore, several neurological impairments, including cognitive, behavioral, and motor dysfunctions, are known to be associated with cerebral malaria. Also, the available evidence has implicated glutamate and glutamatergic pathways, coupled with a resultant alteration in serotonin, dopamine, norepinephrine, and histamine production. While seeking to improve our understanding of the pathophysiology of cerebral malaria, this article seeks to explore the possible links between host/parasite chaperones, and neurotransmitters, in relation to other molecular players in the pathology of cerebral malaria, to explore such links in antimalarial drug discovery.
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spelling pubmed-94510492022-09-08 Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link? Daniyan, Michael Oluwatoyin Fisusi, Funmilola Adesodun Adeoye, Olufunso Bayo Front Mol Biosci Molecular Biosciences Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria. Among the proposed hypotheses that seek to explain the manifestation of the neurological syndrome in cerebral malaria is the vascular occlusion/sequestration/mechanic hypothesis, the cytokine storm or inflammatory theory, or a combination of both. Unfortunately, despite the increasing volume of scientific information on cerebral malaria, our understanding of its pathophysiologic mechanism(s) is still very limited. In a bid to maintain its survival and development, P. falciparum exports a large number of proteins into the cytosol of the infected host red blood cell. Prominent among these are the P. falciparum erythrocytes membrane protein 1 (PfEMP1), P. falciparum histidine-rich protein II (PfHRP2), and P. falciparum heat shock proteins 70-x (PfHsp70-x). Functional activities and interaction of these proteins with one another and with recruited host resident proteins are critical factors in the pathology of malaria in general and cerebral malaria in particular. Furthermore, several neurological impairments, including cognitive, behavioral, and motor dysfunctions, are known to be associated with cerebral malaria. Also, the available evidence has implicated glutamate and glutamatergic pathways, coupled with a resultant alteration in serotonin, dopamine, norepinephrine, and histamine production. While seeking to improve our understanding of the pathophysiology of cerebral malaria, this article seeks to explore the possible links between host/parasite chaperones, and neurotransmitters, in relation to other molecular players in the pathology of cerebral malaria, to explore such links in antimalarial drug discovery. Frontiers Media S.A. 2022-08-24 /pmc/articles/PMC9451049/ /pubmed/36090033 http://dx.doi.org/10.3389/fmolb.2022.965569 Text en Copyright © 2022 Daniyan, Fisusi and Adeoye. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Daniyan, Michael Oluwatoyin
Fisusi, Funmilola Adesodun
Adeoye, Olufunso Bayo
Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
title Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
title_full Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
title_fullStr Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
title_full_unstemmed Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
title_short Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?
title_sort neurotransmitters and molecular chaperones interactions in cerebral malaria: is there a missing link?
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451049/
https://www.ncbi.nlm.nih.gov/pubmed/36090033
http://dx.doi.org/10.3389/fmolb.2022.965569
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