Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2

RNA replication and transcription machinery is an important drug target for fighting against coronavirus. Non-structure protein nsp8 was proposed harboring primase activity. However, the RNA primer synthesis mechanism of nsp8 is still largely unknown. Here, we purified dimer and tetramer forms of SA...

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Detalles Bibliográficos
Autores principales: Xu, Jinxin, Jiang, Xin, Zhang, Yulong, Dong, Yan, Ma, Changli, Jiang, Hanqiu, Zuo, Taisen, Chen, Rui, Ke, Yubin, Cheng, He, Wang, Howard, Liu, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451113/
https://www.ncbi.nlm.nih.gov/pubmed/36071105
http://dx.doi.org/10.1038/s42003-022-03892-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451113/
https://www.ncbi.nlm.nih.gov/pubmed/36071105
http://dx.doi.org/10.1038/s42003-022-03892-x

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