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Two cooperative binding sites sensitize PI(4,5)P(2) recognition by the tubby domain

Phosphoinositides (PIs) are lipid signaling molecules that operate by recruiting proteins to cellular membranes via PI recognition domains. The dominant PI of the plasma membrane is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. One of only two PI(4,5)P(2) recognition domains characterized in...

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Detalles Bibliográficos
Autores principales:	Thallmair, Veronika, Schultz, Lea, Zhao, Wencai, Marrink, Siewert J., Oliver, Dominik, Thallmair, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451155/ https://www.ncbi.nlm.nih.gov/pubmed/36070381 http://dx.doi.org/10.1126/sciadv.abp9471

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