Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function

TET (ten-eleven translocation) enzymes catalyze the oxidation of 5-methylcytosine bases in DNA, thus driving active and passive DNA demethylation. Here, we report that the catalytic domain of mammalian TET enzymes favor CGs embedded within basic helix-loop-helix and basic leucine zipper domain trans...

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Detalles Bibliográficos
Autores principales: Ravichandran, Mirunalini, Rafalski, Dominik, Davies, Claudia I., Ortega-Recalde, Oscar, Nan, Xinsheng, Glanfield, Cassandra R., Kotter, Annika, Misztal, Katarzyna, Wang, Andrew H., Wojciechowski, Marek, Rażew, Michał, Mayyas, Issam M., Kardailsky, Olga, Schwartz, Uwe, Zembrzycki, Krzysztof, Morison, Ian M., Helm, Mark, Weichenhan, Dieter, Jurkowska, Renata Z., Krueger, Felix, Plass, Christoph, Zacharias, Martin, Bochtler, Matthias, Hore, Timothy A., Jurkowski, Tomasz P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451156/
https://www.ncbi.nlm.nih.gov/pubmed/36070377
http://dx.doi.org/10.1126/sciadv.abm2427

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