MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. Th...

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Detalles Bibliográficos
Autores principales: Vondrakova, Jana, Frolikova, Michaela, Ded, Lukas, Cerny, Jiri, Postlerova, Pavla, Palenikova, Veronika, Simonik, Ondrej, Nahacka, Zuzana, Basus, Krystof, Valaskova, Eliska, Machan, Radek, Pacey, Allan, Holubcova, Zuzana, Koubek, Pavel, Ezrova, Zuzana, Park, Soojin, Liu, Ruiwu, Partha, Raghavendran, Clark, Nathan, Neuzil, Jiri, Ikawa, Masahito, Erickson, Kent, Lam, Kit S., Moore, Harry, Komrskova, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451160/
https://www.ncbi.nlm.nih.gov/pubmed/36070373
http://dx.doi.org/10.1126/sciadv.abn0047
Descripción
Sumario:Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.

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