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MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. Th...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451160/ https://www.ncbi.nlm.nih.gov/pubmed/36070373 http://dx.doi.org/10.1126/sciadv.abn0047 |
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| author | Vondrakova, Jana Frolikova, Michaela Ded, Lukas Cerny, Jiri Postlerova, Pavla Palenikova, Veronika Simonik, Ondrej Nahacka, Zuzana Basus, Krystof Valaskova, Eliska Machan, Radek Pacey, Allan Holubcova, Zuzana Koubek, Pavel Ezrova, Zuzana Park, Soojin Liu, Ruiwu Partha, Raghavendran Clark, Nathan Neuzil, Jiri Ikawa, Masahito Erickson, Kent Lam, Kit S. Moore, Harry Komrskova, Katerina |
| author_facet | Vondrakova, Jana Frolikova, Michaela Ded, Lukas Cerny, Jiri Postlerova, Pavla Palenikova, Veronika Simonik, Ondrej Nahacka, Zuzana Basus, Krystof Valaskova, Eliska Machan, Radek Pacey, Allan Holubcova, Zuzana Koubek, Pavel Ezrova, Zuzana Park, Soojin Liu, Ruiwu Partha, Raghavendran Clark, Nathan Neuzil, Jiri Ikawa, Masahito Erickson, Kent Lam, Kit S. Moore, Harry Komrskova, Katerina |
| author_sort | Vondrakova, Jana |
| collection | PubMed |
| description | Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes. |
| format | Online Article Text |
| id | pubmed-9451160 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Association for the Advancement of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94511602022-09-29 MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization Vondrakova, Jana Frolikova, Michaela Ded, Lukas Cerny, Jiri Postlerova, Pavla Palenikova, Veronika Simonik, Ondrej Nahacka, Zuzana Basus, Krystof Valaskova, Eliska Machan, Radek Pacey, Allan Holubcova, Zuzana Koubek, Pavel Ezrova, Zuzana Park, Soojin Liu, Ruiwu Partha, Raghavendran Clark, Nathan Neuzil, Jiri Ikawa, Masahito Erickson, Kent Lam, Kit S. Moore, Harry Komrskova, Katerina Sci Adv Biomedicine and Life Sciences Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor–like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes. American Association for the Advancement of Science 2022-09-07 /pmc/articles/PMC9451160/ /pubmed/36070373 http://dx.doi.org/10.1126/sciadv.abn0047 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| spellingShingle | Biomedicine and Life Sciences Vondrakova, Jana Frolikova, Michaela Ded, Lukas Cerny, Jiri Postlerova, Pavla Palenikova, Veronika Simonik, Ondrej Nahacka, Zuzana Basus, Krystof Valaskova, Eliska Machan, Radek Pacey, Allan Holubcova, Zuzana Koubek, Pavel Ezrova, Zuzana Park, Soojin Liu, Ruiwu Partha, Raghavendran Clark, Nathan Neuzil, Jiri Ikawa, Masahito Erickson, Kent Lam, Kit S. Moore, Harry Komrskova, Katerina MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization |
| title | MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization |
| title_full | MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization |
| title_fullStr | MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization |
| title_full_unstemmed | MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization |
| title_short | MAIA, Fc receptor–like 3, supersedes JUNO as IZUMO1 receptor during human fertilization |
| title_sort | maia, fc receptor–like 3, supersedes juno as izumo1 receptor during human fertilization |
| topic | Biomedicine and Life Sciences |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451160/ https://www.ncbi.nlm.nih.gov/pubmed/36070373 http://dx.doi.org/10.1126/sciadv.abn0047 |
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