A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature

We describe four cases of COVID-19 infection during the Omicron wave, in patients treated with anti-CD20 monoclonal antibodies. All cases follow a similar biphasic clinical course consisting of respiratory deterioration, which occurred a few weeks after convalescence from initial mild to asymptomati...

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Autores principales: Bigman-Peer, Noa, Peer, Eyal, Pertzov, Barak, Kramer, Mordechai, Segal, Gad, Eliakim-Raz, Noa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451519/
https://www.ncbi.nlm.nih.gov/pubmed/36093299
http://dx.doi.org/10.12890/2022_003502
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author Bigman-Peer, Noa
Peer, Eyal
Pertzov, Barak
Kramer, Mordechai
Segal, Gad
Eliakim-Raz, Noa
author_facet Bigman-Peer, Noa
Peer, Eyal
Pertzov, Barak
Kramer, Mordechai
Segal, Gad
Eliakim-Raz, Noa
author_sort Bigman-Peer, Noa
collection PubMed
description We describe four cases of COVID-19 infection during the Omicron wave, in patients treated with anti-CD20 monoclonal antibodies. All cases follow a similar biphasic clinical course consisting of respiratory deterioration, which occurred a few weeks after convalescence from initial mild to asymptomatic infection. Possible explanations are discussed. LEARNING POINTS: Four cases of COVID-19 infection in anti-CD20 treated patients are described. These cases display a unique biphasic course that was previously undescribed: respiratory deterioration weeks after convalescence. Awareness of such a course and rapid utilisation of bronchoalveolar lavage will lead to quicker diagnosis and more timely, appropriate treatment.
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spelling pubmed-94515192022-09-08 A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature Bigman-Peer, Noa Peer, Eyal Pertzov, Barak Kramer, Mordechai Segal, Gad Eliakim-Raz, Noa Eur J Case Rep Intern Med Articles We describe four cases of COVID-19 infection during the Omicron wave, in patients treated with anti-CD20 monoclonal antibodies. All cases follow a similar biphasic clinical course consisting of respiratory deterioration, which occurred a few weeks after convalescence from initial mild to asymptomatic infection. Possible explanations are discussed. LEARNING POINTS: Four cases of COVID-19 infection in anti-CD20 treated patients are described. These cases display a unique biphasic course that was previously undescribed: respiratory deterioration weeks after convalescence. Awareness of such a course and rapid utilisation of bronchoalveolar lavage will lead to quicker diagnosis and more timely, appropriate treatment. SMC Media Srl 2022-08-31 /pmc/articles/PMC9451519/ /pubmed/36093299 http://dx.doi.org/10.12890/2022_003502 Text en © EFIM 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Articles
Bigman-Peer, Noa
Peer, Eyal
Pertzov, Barak
Kramer, Mordechai
Segal, Gad
Eliakim-Raz, Noa
A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature
title A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature
title_full A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature
title_fullStr A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature
title_full_unstemmed A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature
title_short A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature
title_sort biphasic covid-19 clinical course in anti-cd20 treated patients: case series and review of the literature
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451519/
https://www.ncbi.nlm.nih.gov/pubmed/36093299
http://dx.doi.org/10.12890/2022_003502
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