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Impact of blindness onset on the representation of sound categories in occipital and temporal cortices

The ventral occipito-temporal cortex (VOTC) reliably encodes auditory categories in people born blind using a representational structure partially similar to the one found in vision (Mattioni et al.,2020). Here, using a combination of uni- and multivoxel analyses applied to fMRI data, we extend our...

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Autores principales: Mattioni, Stefania, Rezk, Mohamed, Battal, Ceren, Vadlamudi, Jyothirmayi, Collignon, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451537/
https://www.ncbi.nlm.nih.gov/pubmed/36070354
http://dx.doi.org/10.7554/eLife.79370
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author Mattioni, Stefania
Rezk, Mohamed
Battal, Ceren
Vadlamudi, Jyothirmayi
Collignon, Olivier
author_facet Mattioni, Stefania
Rezk, Mohamed
Battal, Ceren
Vadlamudi, Jyothirmayi
Collignon, Olivier
author_sort Mattioni, Stefania
collection PubMed
description The ventral occipito-temporal cortex (VOTC) reliably encodes auditory categories in people born blind using a representational structure partially similar to the one found in vision (Mattioni et al.,2020). Here, using a combination of uni- and multivoxel analyses applied to fMRI data, we extend our previous findings, comprehensively investigating how early and late acquired blindness impact on the cortical regions coding for the deprived and the remaining senses. First, we show enhanced univariate response to sounds in part of the occipital cortex of both blind groups that is concomitant to reduced auditory responses in temporal regions. We then reveal that the representation of the sound categories in the occipital and temporal regions is more similar in blind subjects compared to sighted subjects. What could drive this enhanced similarity? The multivoxel encoding of the ‘human voice’ category that we observed in the temporal cortex of all sighted and blind groups is enhanced in occipital regions in blind groups , suggesting that the representation of vocal information is more similar between the occipital and temporal regions in blind compared to sighted individuals. We additionally show that blindness does not affect the encoding of the acoustic properties of our sounds (e.g. pitch, harmonicity) in occipital and in temporal regions but instead selectively alter the categorical coding of the voice category itself. These results suggest a functionally congruent interplay between the reorganization of occipital and temporal regions following visual deprivation, across the lifespan.
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spelling pubmed-94515372022-09-08 Impact of blindness onset on the representation of sound categories in occipital and temporal cortices Mattioni, Stefania Rezk, Mohamed Battal, Ceren Vadlamudi, Jyothirmayi Collignon, Olivier eLife Neuroscience The ventral occipito-temporal cortex (VOTC) reliably encodes auditory categories in people born blind using a representational structure partially similar to the one found in vision (Mattioni et al.,2020). Here, using a combination of uni- and multivoxel analyses applied to fMRI data, we extend our previous findings, comprehensively investigating how early and late acquired blindness impact on the cortical regions coding for the deprived and the remaining senses. First, we show enhanced univariate response to sounds in part of the occipital cortex of both blind groups that is concomitant to reduced auditory responses in temporal regions. We then reveal that the representation of the sound categories in the occipital and temporal regions is more similar in blind subjects compared to sighted subjects. What could drive this enhanced similarity? The multivoxel encoding of the ‘human voice’ category that we observed in the temporal cortex of all sighted and blind groups is enhanced in occipital regions in blind groups , suggesting that the representation of vocal information is more similar between the occipital and temporal regions in blind compared to sighted individuals. We additionally show that blindness does not affect the encoding of the acoustic properties of our sounds (e.g. pitch, harmonicity) in occipital and in temporal regions but instead selectively alter the categorical coding of the voice category itself. These results suggest a functionally congruent interplay between the reorganization of occipital and temporal regions following visual deprivation, across the lifespan. eLife Sciences Publications, Ltd 2022-09-07 /pmc/articles/PMC9451537/ /pubmed/36070354 http://dx.doi.org/10.7554/eLife.79370 Text en © 2022, Mattioni et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Mattioni, Stefania
Rezk, Mohamed
Battal, Ceren
Vadlamudi, Jyothirmayi
Collignon, Olivier
Impact of blindness onset on the representation of sound categories in occipital and temporal cortices
title Impact of blindness onset on the representation of sound categories in occipital and temporal cortices
title_full Impact of blindness onset on the representation of sound categories in occipital and temporal cortices
title_fullStr Impact of blindness onset on the representation of sound categories in occipital and temporal cortices
title_full_unstemmed Impact of blindness onset on the representation of sound categories in occipital and temporal cortices
title_short Impact of blindness onset on the representation of sound categories in occipital and temporal cortices
title_sort impact of blindness onset on the representation of sound categories in occipital and temporal cortices
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451537/
https://www.ncbi.nlm.nih.gov/pubmed/36070354
http://dx.doi.org/10.7554/eLife.79370
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