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Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings
We estimated the optimum time to initiate antiretroviral therapy (ART) in a retrospective observational cohort. We observed that ART initiation 7 days or less (n = 817) and 8–30 days (n = 1009) were the most important factors with viral suppression, and had similar viral suppression rate, CD4(+) T-c...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Lippincott Williams & Wilkins
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451863/ https://www.ncbi.nlm.nih.gov/pubmed/35866529 http://dx.doi.org/10.1097/QAD.0000000000003327 |
| _version_ | 1784784817178542080 |
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| author | Zhao, Bin Ding, Haibo Song, Wei Kang, Mingming Dong, Xue Li, Xin Wang, Lu Liu, Jianmin Chu, Zhenxing Wang, Lin Tian, Wen Qiu, Yu Shang, Hong Han, Xiaoxu |
| author_facet | Zhao, Bin Ding, Haibo Song, Wei Kang, Mingming Dong, Xue Li, Xin Wang, Lu Liu, Jianmin Chu, Zhenxing Wang, Lin Tian, Wen Qiu, Yu Shang, Hong Han, Xiaoxu |
| author_sort | Zhao, Bin |
| collection | PubMed |
| description | We estimated the optimum time to initiate antiretroviral therapy (ART) in a retrospective observational cohort. We observed that ART initiation 7 days or less (n = 817) and 8–30 days (n = 1009) were the most important factors with viral suppression, and had similar viral suppression rate, CD4(+) T-cell count increase and fractions of individuals with links at least 4 and individuals linked to recent HIV infection in HIV molecular networks. This study provides real-world evidence on the benefits of rapid ART initiation in resource-limited setting. |
| format | Online Article Text |
| id | pubmed-9451863 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Lippincott Williams & Wilkins |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94518632022-09-13 Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings Zhao, Bin Ding, Haibo Song, Wei Kang, Mingming Dong, Xue Li, Xin Wang, Lu Liu, Jianmin Chu, Zhenxing Wang, Lin Tian, Wen Qiu, Yu Shang, Hong Han, Xiaoxu AIDS Research Letter We estimated the optimum time to initiate antiretroviral therapy (ART) in a retrospective observational cohort. We observed that ART initiation 7 days or less (n = 817) and 8–30 days (n = 1009) were the most important factors with viral suppression, and had similar viral suppression rate, CD4(+) T-cell count increase and fractions of individuals with links at least 4 and individuals linked to recent HIV infection in HIV molecular networks. This study provides real-world evidence on the benefits of rapid ART initiation in resource-limited setting. Lippincott Williams & Wilkins 2022-10-01 2022-07-09 /pmc/articles/PMC9451863/ /pubmed/35866529 http://dx.doi.org/10.1097/QAD.0000000000003327 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
| spellingShingle | Research Letter Zhao, Bin Ding, Haibo Song, Wei Kang, Mingming Dong, Xue Li, Xin Wang, Lu Liu, Jianmin Chu, Zhenxing Wang, Lin Tian, Wen Qiu, Yu Shang, Hong Han, Xiaoxu Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings |
| title | Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings |
| title_full | Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings |
| title_fullStr | Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings |
| title_full_unstemmed | Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings |
| title_short | Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings |
| title_sort | antiretroviral therapy initiation within 7 and 8–30 days post-hiv diagnosis demonstrates similar benefits in resource-limited settings |
| topic | Research Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9451863/ https://www.ncbi.nlm.nih.gov/pubmed/35866529 http://dx.doi.org/10.1097/QAD.0000000000003327 |
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