Cargando…

Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the production of autoantibodies against the platelet surface antigens. ITP is a diagnosis of exclusion and is further categorized into primary and secondary ITP. The etiology of primary ITP is idiopathic, and secondary ITP is c...

Descripción completa

Detalles Bibliográficos
Autores principales: Sadia, Haleema, Abro, Sheeraz, Ali, Muneeba, Uddin, Khalid, Agboola, Adesola A, Bano, Shehar, Anigbo, Chinyere L, Singh, Romil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452057/
https://www.ncbi.nlm.nih.gov/pubmed/36106209
http://dx.doi.org/10.7759/cureus.27809
_version_ 1784784860480536576
author Sadia, Haleema
Abro, Sheeraz
Ali, Muneeba
Uddin, Khalid
Agboola, Adesola A
Bano, Shehar
Anigbo, Chinyere L
Singh, Romil
author_facet Sadia, Haleema
Abro, Sheeraz
Ali, Muneeba
Uddin, Khalid
Agboola, Adesola A
Bano, Shehar
Anigbo, Chinyere L
Singh, Romil
author_sort Sadia, Haleema
collection PubMed
description Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the production of autoantibodies against the platelet surface antigens. ITP is a diagnosis of exclusion and is further categorized into primary and secondary ITP. The etiology of primary ITP is idiopathic, and secondary ITP is caused by infections and autoimmune disorders. Among infectious etiology of ITP, human immunodeficiency virus, herpes virus, and hepatitis B and C virus are common. Helicobacter pylori (H. pylori) is a rare cause of ITP, and the relationship between ITP and H. pylori is highlighted in the literature. We report a case of ITP in an adult female who presented with hematemesis and petechial rash in the lower limbs. Her initial laboratory results demonstrated thrombocytopenia, and the results of her gastric biopsy and stool antigen were positive for H. pylori. She was diagnosed with ITP induced by H. pylori because additional causes of ITP were not identified. Her clinical improvement and platelet recovery after initiating H. pylori eradication therapy were consistent with H. pylori-induced ITP.
format Online
Article
Text
id pubmed-9452057
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-94520572022-09-13 Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review Sadia, Haleema Abro, Sheeraz Ali, Muneeba Uddin, Khalid Agboola, Adesola A Bano, Shehar Anigbo, Chinyere L Singh, Romil Cureus Internal Medicine Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the production of autoantibodies against the platelet surface antigens. ITP is a diagnosis of exclusion and is further categorized into primary and secondary ITP. The etiology of primary ITP is idiopathic, and secondary ITP is caused by infections and autoimmune disorders. Among infectious etiology of ITP, human immunodeficiency virus, herpes virus, and hepatitis B and C virus are common. Helicobacter pylori (H. pylori) is a rare cause of ITP, and the relationship between ITP and H. pylori is highlighted in the literature. We report a case of ITP in an adult female who presented with hematemesis and petechial rash in the lower limbs. Her initial laboratory results demonstrated thrombocytopenia, and the results of her gastric biopsy and stool antigen were positive for H. pylori. She was diagnosed with ITP induced by H. pylori because additional causes of ITP were not identified. Her clinical improvement and platelet recovery after initiating H. pylori eradication therapy were consistent with H. pylori-induced ITP. Cureus 2022-08-09 /pmc/articles/PMC9452057/ /pubmed/36106209 http://dx.doi.org/10.7759/cureus.27809 Text en Copyright © 2022, Sadia et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Sadia, Haleema
Abro, Sheeraz
Ali, Muneeba
Uddin, Khalid
Agboola, Adesola A
Bano, Shehar
Anigbo, Chinyere L
Singh, Romil
Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review
title Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review
title_full Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review
title_fullStr Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review
title_full_unstemmed Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review
title_short Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review
title_sort immune thrombocytopenia induced by helicobacter pylori infection: a case report and literature review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452057/
https://www.ncbi.nlm.nih.gov/pubmed/36106209
http://dx.doi.org/10.7759/cureus.27809
work_keys_str_mv AT sadiahaleema immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview
AT abrosheeraz immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview
AT alimuneeba immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview
AT uddinkhalid immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview
AT agboolaadesolaa immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview
AT banoshehar immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview
AT anigbochinyerel immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview
AT singhromil immunethrombocytopeniainducedbyhelicobacterpyloriinfectionacasereportandliteraturereview