Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality

In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19...

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Autores principales: Rocco, Joseph M, Laghetti, Paola, Di Stefano, Mariantonietta, Sereti, Irini, Ortega-Villa, Ana, Wang, Jing, Rupert, Adam, Chironna, Maria, Ye, Peiying, Liu, Xiangdong, Anderson, Megan V, Burbelo, Peter B, Fiore, Jose Ramon, Saracino, Annalisa, Lisco, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452087/
https://www.ncbi.nlm.nih.gov/pubmed/36111172
http://dx.doi.org/10.1093/ofid/ofac427
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author Rocco, Joseph M
Laghetti, Paola
Di Stefano, Mariantonietta
Sereti, Irini
Ortega-Villa, Ana
Wang, Jing
Rupert, Adam
Chironna, Maria
Ye, Peiying
Liu, Xiangdong
Anderson, Megan V
Burbelo, Peter B
Fiore, Jose Ramon
Saracino, Annalisa
Lisco, Andrea
author_facet Rocco, Joseph M
Laghetti, Paola
Di Stefano, Mariantonietta
Sereti, Irini
Ortega-Villa, Ana
Wang, Jing
Rupert, Adam
Chironna, Maria
Ye, Peiying
Liu, Xiangdong
Anderson, Megan V
Burbelo, Peter B
Fiore, Jose Ramon
Saracino, Annalisa
Lisco, Andrea
author_sort Rocco, Joseph M
collection PubMed
description In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.
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spelling pubmed-94520872022-09-09 Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality Rocco, Joseph M Laghetti, Paola Di Stefano, Mariantonietta Sereti, Irini Ortega-Villa, Ana Wang, Jing Rupert, Adam Chironna, Maria Ye, Peiying Liu, Xiangdong Anderson, Megan V Burbelo, Peter B Fiore, Jose Ramon Saracino, Annalisa Lisco, Andrea Open Forum Infect Dis Brief Report In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals. Oxford University Press 2022-08-20 /pmc/articles/PMC9452087/ /pubmed/36111172 http://dx.doi.org/10.1093/ofid/ofac427 Text en Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Brief Report
Rocco, Joseph M
Laghetti, Paola
Di Stefano, Mariantonietta
Sereti, Irini
Ortega-Villa, Ana
Wang, Jing
Rupert, Adam
Chironna, Maria
Ye, Peiying
Liu, Xiangdong
Anderson, Megan V
Burbelo, Peter B
Fiore, Jose Ramon
Saracino, Annalisa
Lisco, Andrea
Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
title Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
title_full Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
title_fullStr Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
title_full_unstemmed Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
title_short Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality
title_sort impact of innate immunity, endothelial damage, and metabolic biomarkers on covid-19 severity and mortality
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452087/
https://www.ncbi.nlm.nih.gov/pubmed/36111172
http://dx.doi.org/10.1093/ofid/ofac427
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