Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD

BACKGROUND: The safety of a third dose of SARS-CoV-2 mRNA vaccination in patients with inflammatory bowel disease is unknown. METHODS: We compared symptoms following a third SARS-CoV-2 mRNA vaccine dose with symptoms after the second dose in IBD. RESULTS: The study group included 594 patients (70% f...

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Autores principales: Li, Dalin, Debbas, Philip, Mujukian, Angela, Cheng, Susan, Braun, Jonathan, McGovern, Dermot P B, Melmed, Gil Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452161/
https://www.ncbi.nlm.nih.gov/pubmed/35998072
http://dx.doi.org/10.1093/ibd/izac174
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author Li, Dalin
Debbas, Philip
Mujukian, Angela
Cheng, Susan
Braun, Jonathan
McGovern, Dermot P B
Melmed, Gil Y
author_facet Li, Dalin
Debbas, Philip
Mujukian, Angela
Cheng, Susan
Braun, Jonathan
McGovern, Dermot P B
Melmed, Gil Y
author_sort Li, Dalin
collection PubMed
description BACKGROUND: The safety of a third dose of SARS-CoV-2 mRNA vaccination in patients with inflammatory bowel disease is unknown. METHODS: We compared symptoms following a third SARS-CoV-2 mRNA vaccine dose with symptoms after the second dose in IBD. RESULTS: The study group included 594 patients (70% female, 58% BNT162b2). Overall, 41% reported symptoms after a third dose. Symptom frequency and severity were lower after the third dose relative to the second dose for every organ system, except for gastrointestinal symptoms which were marginally worse. CONCLUSION: The frequency and severity of symptoms after a third mRNA vaccine dose are generally similar or milder than after a second dose for most organ systems.
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spelling pubmed-94521612022-09-09 Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD Li, Dalin Debbas, Philip Mujukian, Angela Cheng, Susan Braun, Jonathan McGovern, Dermot P B Melmed, Gil Y Inflamm Bowel Dis Clinical Research BACKGROUND: The safety of a third dose of SARS-CoV-2 mRNA vaccination in patients with inflammatory bowel disease is unknown. METHODS: We compared symptoms following a third SARS-CoV-2 mRNA vaccine dose with symptoms after the second dose in IBD. RESULTS: The study group included 594 patients (70% female, 58% BNT162b2). Overall, 41% reported symptoms after a third dose. Symptom frequency and severity were lower after the third dose relative to the second dose for every organ system, except for gastrointestinal symptoms which were marginally worse. CONCLUSION: The frequency and severity of symptoms after a third mRNA vaccine dose are generally similar or milder than after a second dose for most organ systems. Oxford University Press 2022-08-23 /pmc/articles/PMC9452161/ /pubmed/35998072 http://dx.doi.org/10.1093/ibd/izac174 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com https://academic.oup.com/pages/standard-publication-reuse-rightsThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
spellingShingle Clinical Research
Li, Dalin
Debbas, Philip
Mujukian, Angela
Cheng, Susan
Braun, Jonathan
McGovern, Dermot P B
Melmed, Gil Y
Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD
title Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD
title_full Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD
title_fullStr Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD
title_full_unstemmed Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD
title_short Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD
title_sort postvaccination symptoms after a third dose of mrna sars-cov-2 vaccination in patients with inflammatory bowel disease: results from corale-ibd
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452161/
https://www.ncbi.nlm.nih.gov/pubmed/35998072
http://dx.doi.org/10.1093/ibd/izac174
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