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SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases

Building realistically complex models of infectious disease transmission that are relevant for informing public health is conceptually challenging and requires knowledge of coding architecture that can implement key modeling conventions. For example, many of the models built to understand COVID-19 d...

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Autores principales: Mihaljevic, Joseph R, Borkovec, Seth, Ratnavale, Saikanth, Hocking, Toby D, Banister, Kelsey E, Eppinger, Joseph E, Hepp, Crystal, Doerry, Eck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452174/
https://www.ncbi.nlm.nih.gov/pubmed/36157711
http://dx.doi.org/10.1093/biomethods/bpac022
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author Mihaljevic, Joseph R
Borkovec, Seth
Ratnavale, Saikanth
Hocking, Toby D
Banister, Kelsey E
Eppinger, Joseph E
Hepp, Crystal
Doerry, Eck
author_facet Mihaljevic, Joseph R
Borkovec, Seth
Ratnavale, Saikanth
Hocking, Toby D
Banister, Kelsey E
Eppinger, Joseph E
Hepp, Crystal
Doerry, Eck
author_sort Mihaljevic, Joseph R
collection PubMed
description Building realistically complex models of infectious disease transmission that are relevant for informing public health is conceptually challenging and requires knowledge of coding architecture that can implement key modeling conventions. For example, many of the models built to understand COVID-19 dynamics have included stochasticity, transmission dynamics that change throughout the epidemic due to changes in host behavior or public health interventions, and spatial structures that account for important spatio-temporal heterogeneities. Here we introduce an R package, SPARSEMODr, that allows users to simulate disease models that are stochastic and spatially explicit, including a model for COVID-19 that was useful in the early phases of the epidemic. SPARSEMOD stands for SPAtial Resolution-SEnsitive Models of Outbreak Dynamics, and our goal is to demonstrate particular conventions for rapidly simulating the dynamics of more complex, spatial models of infectious disease. In this report, we outline the features and workflows of our software package that allow for user-customized simulations. We believe the example models provided in our package will be useful in educational settings, as the coding conventions are adaptable, and will help new modelers to better understand important assumptions that were built into sophisticated COVID-19 models.
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spelling pubmed-94521742022-09-09 SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases Mihaljevic, Joseph R Borkovec, Seth Ratnavale, Saikanth Hocking, Toby D Banister, Kelsey E Eppinger, Joseph E Hepp, Crystal Doerry, Eck Biol Methods Protoc Methods Article Building realistically complex models of infectious disease transmission that are relevant for informing public health is conceptually challenging and requires knowledge of coding architecture that can implement key modeling conventions. For example, many of the models built to understand COVID-19 dynamics have included stochasticity, transmission dynamics that change throughout the epidemic due to changes in host behavior or public health interventions, and spatial structures that account for important spatio-temporal heterogeneities. Here we introduce an R package, SPARSEMODr, that allows users to simulate disease models that are stochastic and spatially explicit, including a model for COVID-19 that was useful in the early phases of the epidemic. SPARSEMOD stands for SPAtial Resolution-SEnsitive Models of Outbreak Dynamics, and our goal is to demonstrate particular conventions for rapidly simulating the dynamics of more complex, spatial models of infectious disease. In this report, we outline the features and workflows of our software package that allow for user-customized simulations. We believe the example models provided in our package will be useful in educational settings, as the coding conventions are adaptable, and will help new modelers to better understand important assumptions that were built into sophisticated COVID-19 models. Oxford University Press 2022-09-01 /pmc/articles/PMC9452174/ /pubmed/36157711 http://dx.doi.org/10.1093/biomethods/bpac022 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Methods Article
Mihaljevic, Joseph R
Borkovec, Seth
Ratnavale, Saikanth
Hocking, Toby D
Banister, Kelsey E
Eppinger, Joseph E
Hepp, Crystal
Doerry, Eck
SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases
title SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases
title_full SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases
title_fullStr SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases
title_full_unstemmed SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases
title_short SPARSEMODr: Rapidly simulate spatially explicit and stochastic models of COVID-19 and other infectious diseases
title_sort sparsemodr: rapidly simulate spatially explicit and stochastic models of covid-19 and other infectious diseases
topic Methods Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452174/
https://www.ncbi.nlm.nih.gov/pubmed/36157711
http://dx.doi.org/10.1093/biomethods/bpac022
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