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Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy()
INTRODUCTION: The Human Immunodeficiency Virus (HIV) and infections related to it can affect multiple sites in the hearing system. The use of High Activity Anti-Retroviral Therapy (HAART) can cause side effects such as ototoxicity. Thus, no consistent patterns of hearing impairment in adults with Hu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452257/ https://www.ncbi.nlm.nih.gov/pubmed/28823692 http://dx.doi.org/10.1016/j.bjorl.2017.07.003 |
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author | Matas, Carla Gentile Samelli, Alessandra Giannella Magliaro, Fernanda Cristina Leite Segurado, Aluisio |
author_facet | Matas, Carla Gentile Samelli, Alessandra Giannella Magliaro, Fernanda Cristina Leite Segurado, Aluisio |
author_sort | Matas, Carla Gentile |
collection | PubMed |
description | INTRODUCTION: The Human Immunodeficiency Virus (HIV) and infections related to it can affect multiple sites in the hearing system. The use of High Activity Anti-Retroviral Therapy (HAART) can cause side effects such as ototoxicity. Thus, no consistent patterns of hearing impairment in adults with Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome have been established, and the problems that affect the hearing system of this population warrant further research. OBJECTIVES: This study aimed to compare the audiological and electrophysiological data of Human Immunodeficiency Virus-positive patients with and without Acquired Immune Deficiency Syndrome, who were receiving High Activity Anti-Retroviral Therapy, to healthy individuals. METHODS: It was a cross-sectional study conducted with 71 subjects (30–48 years old), divided into groups: Research Group I: 16 Human Immunodeficiency Virus-positive individuals without Acquired Immunodeficiency Syndrome (not receiving antiretroviral treatment); Research Group II: 25 Human Immunodeficiency Virus-positive individuals with Acquired Immunodeficiency Syndrome (receiving antiretroviral treatment); Control Group: 30 healthy subjects. All individuals were tested by pure-tone air conduction thresholds at 0.25–8 kHz, extended high frequencies at 9–20 kHz, electrophysiological tests (Auditory Brainstem Response, Middle Latency Responses, Cognitive Potential). RESULTS: Research Group I and Research Group II had higher hearing thresholds in both conventional and high frequency audiometry when compared to the control group, prolonged latency of waves I, III, V and interpeak I–V in Auditory Brainstem Response and prolonged latency of P300 Cognitive Potential. Regarding Middle Latency Responses, there was a decrease in the amplitude of the Pa wave of Research Group II compared to the Research Group I. CONCLUSIONS: Both groups with Human Immunodeficiency Virus had higher hearing thresholds when compared to healthy individuals (group exposed to antiretroviral treatment showed the worst hearing threshold) and seemed to have lower neuroelectric transmission speed along the auditory pathway in the brainstem, subcortical and cortical regions. |
format | Online Article Text |
id | pubmed-9452257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94522572022-09-09 Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy() Matas, Carla Gentile Samelli, Alessandra Giannella Magliaro, Fernanda Cristina Leite Segurado, Aluisio Braz J Otorhinolaryngol Original Article INTRODUCTION: The Human Immunodeficiency Virus (HIV) and infections related to it can affect multiple sites in the hearing system. The use of High Activity Anti-Retroviral Therapy (HAART) can cause side effects such as ototoxicity. Thus, no consistent patterns of hearing impairment in adults with Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome have been established, and the problems that affect the hearing system of this population warrant further research. OBJECTIVES: This study aimed to compare the audiological and electrophysiological data of Human Immunodeficiency Virus-positive patients with and without Acquired Immune Deficiency Syndrome, who were receiving High Activity Anti-Retroviral Therapy, to healthy individuals. METHODS: It was a cross-sectional study conducted with 71 subjects (30–48 years old), divided into groups: Research Group I: 16 Human Immunodeficiency Virus-positive individuals without Acquired Immunodeficiency Syndrome (not receiving antiretroviral treatment); Research Group II: 25 Human Immunodeficiency Virus-positive individuals with Acquired Immunodeficiency Syndrome (receiving antiretroviral treatment); Control Group: 30 healthy subjects. All individuals were tested by pure-tone air conduction thresholds at 0.25–8 kHz, extended high frequencies at 9–20 kHz, electrophysiological tests (Auditory Brainstem Response, Middle Latency Responses, Cognitive Potential). RESULTS: Research Group I and Research Group II had higher hearing thresholds in both conventional and high frequency audiometry when compared to the control group, prolonged latency of waves I, III, V and interpeak I–V in Auditory Brainstem Response and prolonged latency of P300 Cognitive Potential. Regarding Middle Latency Responses, there was a decrease in the amplitude of the Pa wave of Research Group II compared to the Research Group I. CONCLUSIONS: Both groups with Human Immunodeficiency Virus had higher hearing thresholds when compared to healthy individuals (group exposed to antiretroviral treatment showed the worst hearing threshold) and seemed to have lower neuroelectric transmission speed along the auditory pathway in the brainstem, subcortical and cortical regions. Elsevier 2017-08-02 /pmc/articles/PMC9452257/ /pubmed/28823692 http://dx.doi.org/10.1016/j.bjorl.2017.07.003 Text en © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Matas, Carla Gentile Samelli, Alessandra Giannella Magliaro, Fernanda Cristina Leite Segurado, Aluisio Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy() |
title | Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy() |
title_full | Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy() |
title_fullStr | Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy() |
title_full_unstemmed | Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy() |
title_short | Audiological and electrophysiological alterations in HIV-infected individuals subjected or not to antiretroviral therapy() |
title_sort | audiological and electrophysiological alterations in hiv-infected individuals subjected or not to antiretroviral therapy() |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452257/ https://www.ncbi.nlm.nih.gov/pubmed/28823692 http://dx.doi.org/10.1016/j.bjorl.2017.07.003 |
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