MYB orchestrates T cell exhaustion and response to checkpoint inhibition

CD8(+) T cells that respond to chronic viral infections or cancer are characterized by the expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by the impaired production of cytokines. This state of restrained functionality—which is referred to as T cell exhaustion(1...

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Detalles Bibliográficos
Autores principales: Tsui, Carlson, Kretschmer, Lorenz, Rapelius, Svenja, Gabriel, Sarah S., Chisanga, David, Knöpper, Konrad, Utzschneider, Daniel T., Nüssing, Simone, Liao, Yang, Mason, Teisha, Torres, Santiago Valle, Wilcox, Stephen A., Kanev, Krystian, Jarosch, Sebastian, Leube, Justin, Nutt, Stephen L., Zehn, Dietmar, Parish, Ian A., Kastenmüller, Wolfgang, Shi, Wei, Buchholz, Veit R., Kallies, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452299/
https://www.ncbi.nlm.nih.gov/pubmed/35978192
http://dx.doi.org/10.1038/s41586-022-05105-1

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