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Structural basis for SHOC2 modulation of RAS signalling

The RAS–RAF pathway is one of the most commonly dysregulated in human cancers(1–3). Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation(4) of the kinase RAF remains limited. Recent structures of inactive RAF monomer(5) and active RAF dimer(5–8)...

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Detalles Bibliográficos
Autores principales:	Liau, Nicholas P. D., Johnson, Matthew C., Izadi, Saeed, Gerosa, Luca, Hammel, Michal, Bruning, John M., Wendorff, Timothy J., Phung, Wilson, Hymowitz, Sarah G., Sudhamsu, Jawahar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452301/ https://www.ncbi.nlm.nih.gov/pubmed/35768504 http://dx.doi.org/10.1038/s41586-022-04838-3

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