Bidirectional lysosome transport: a balancing act between ARL8 effectors

Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key...

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Detalles Bibliográficos
Autores principales: Kendrick, Agnieszka A., Christensen, Jenna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452499/
https://www.ncbi.nlm.nih.gov/pubmed/36071047
http://dx.doi.org/10.1038/s41467-022-32965-y
Descripción
Sumario:Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.

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