Bidirectional lysosome transport: a balancing act between ARL8 effectors

Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key...

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Autores principales: Kendrick, Agnieszka A., Christensen, Jenna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452499/
https://www.ncbi.nlm.nih.gov/pubmed/36071047
http://dx.doi.org/10.1038/s41467-022-32965-y
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author Kendrick, Agnieszka A.
Christensen, Jenna R.
author_facet Kendrick, Agnieszka A.
Christensen, Jenna R.
author_sort Kendrick, Agnieszka A.
collection PubMed
description Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.
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spelling pubmed-94524992022-09-09 Bidirectional lysosome transport: a balancing act between ARL8 effectors Kendrick, Agnieszka A. Christensen, Jenna R. Nat Commun Comment Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells. Nature Publishing Group UK 2022-09-07 /pmc/articles/PMC9452499/ /pubmed/36071047 http://dx.doi.org/10.1038/s41467-022-32965-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Kendrick, Agnieszka A.
Christensen, Jenna R.
Bidirectional lysosome transport: a balancing act between ARL8 effectors
title Bidirectional lysosome transport: a balancing act between ARL8 effectors
title_full Bidirectional lysosome transport: a balancing act between ARL8 effectors
title_fullStr Bidirectional lysosome transport: a balancing act between ARL8 effectors
title_full_unstemmed Bidirectional lysosome transport: a balancing act between ARL8 effectors
title_short Bidirectional lysosome transport: a balancing act between ARL8 effectors
title_sort bidirectional lysosome transport: a balancing act between arl8 effectors
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452499/
https://www.ncbi.nlm.nih.gov/pubmed/36071047
http://dx.doi.org/10.1038/s41467-022-32965-y
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