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Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP

Opioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower risk profile are needed. (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropionamide (NFEPP) is a novel opioid agonist that preferentially...

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Detalles Bibliográficos
Autores principales:	Celik, Melih Ö., Negrete, Roger, Di Rosso, Riccardo, Machelska, Halina, Stein, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452500/ https://www.ncbi.nlm.nih.gov/pubmed/36071140 http://dx.doi.org/10.1038/s41598-022-19568-9

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