Combination of T cell-redirecting bispecific antibody ERY974 and chemotherapy reciprocally enhances efficacy against non-inflamed tumours

Identifying a strategy with strong efficacy against non-inflamed tumours is vital in cancer immune therapy. ERY974 is a humanized IgG4 bispecific T cell-redirecting antibody that recognizes glypican-3 and CD3. Here we examine the combination effect of ERY974 and chemotherapy (paclitaxel, cisplatin,...

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Detalles Bibliográficos
Autores principales: Sano, Yuji, Azuma, Yumiko, Tsunenari, Toshiaki, Kayukawa, Yoko, Shinozuka, Junko, Fujii, Etsuko, Amano, Jun, Nishito, Yukari, Maruyama, Toru, Kinoshita, Yasuko, Sakamoto, Yuichiro, Yoshida, Ayae, Miyazaki, Yoko, Sato, Yuta, Teramoto-Seida, Chifumi, Ishiguro, Takahiro, Tanaka, Takayoshi, Kitazawa, Takehisa, Endo, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452528/
https://www.ncbi.nlm.nih.gov/pubmed/36071036
http://dx.doi.org/10.1038/s41467-022-32952-3

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