TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance

TENTs generate miRNA isoforms by 3’ tailing. However, little is known about how tailing regulates miRNA function. Here, we generate isogenic HEK293T cell lines in which TENT2, TUT4 and TUT7 are knocked out individually or in combination. Together with rescue experiments, we characterize TENT-specifi...

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Detalles Bibliográficos
Autores principales: Yang, Acong, Bofill-De Ros, Xavier, Stanton, Ryan, Shao, Tie-Juan, Villanueva, Patricia, Gu, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452540/
https://www.ncbi.nlm.nih.gov/pubmed/36071058
http://dx.doi.org/10.1038/s41467-022-32969-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452540/
https://www.ncbi.nlm.nih.gov/pubmed/36071058
http://dx.doi.org/10.1038/s41467-022-32969-8

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