Cargando…

Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease

Clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in Alzheimer’s disease (AD), but the underlying brain circuit mechanisms remain largely unclear. In healthy brains, sharp-wave ripples (SWRs) in the hippocampus and entorhinal cortex play a cr...

Descripción completa

Detalles Bibliográficos
Autores principales: Funane, Tsukasa, Jun, Heechul, Sutoko, Stephanie, Saido, Takaomi C., Kandori, Akihiko, Igarashi, Kei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452631/
https://www.ncbi.nlm.nih.gov/pubmed/36090186
http://dx.doi.org/10.3389/fnsys.2022.955178
_version_ 1784784951179214848
author Funane, Tsukasa
Jun, Heechul
Sutoko, Stephanie
Saido, Takaomi C.
Kandori, Akihiko
Igarashi, Kei M.
author_facet Funane, Tsukasa
Jun, Heechul
Sutoko, Stephanie
Saido, Takaomi C.
Kandori, Akihiko
Igarashi, Kei M.
author_sort Funane, Tsukasa
collection PubMed
description Clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in Alzheimer’s disease (AD), but the underlying brain circuit mechanisms remain largely unclear. In healthy brains, sharp-wave ripples (SWRs) in the hippocampus and entorhinal cortex play a critical role in memory consolidation. We tested SWRs in the MEC layers 2/3 of awake amyloid precursor protein knock-in (APP-KI) mice, recorded simultaneously with SWRs in the hippocampal CA1. We found that MEC→CA1 coordination of SWRs, found previously in healthy brains, was disrupted in APP-KI mice even at a young age before the emergence of spatial memory impairments. Intriguingly, long-duration SWRs critical for memory consolidation were mildly diminished in CA1, although SWR density and amplitude remained intact. Our results point to SWR incoordination in the entorhinal-hippocampal circuit as an early network symptom that precedes memory impairment in AD.
format Online
Article
Text
id pubmed-9452631
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94526312022-09-09 Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease Funane, Tsukasa Jun, Heechul Sutoko, Stephanie Saido, Takaomi C. Kandori, Akihiko Igarashi, Kei M. Front Syst Neurosci Neuroscience Clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in Alzheimer’s disease (AD), but the underlying brain circuit mechanisms remain largely unclear. In healthy brains, sharp-wave ripples (SWRs) in the hippocampus and entorhinal cortex play a critical role in memory consolidation. We tested SWRs in the MEC layers 2/3 of awake amyloid precursor protein knock-in (APP-KI) mice, recorded simultaneously with SWRs in the hippocampal CA1. We found that MEC→CA1 coordination of SWRs, found previously in healthy brains, was disrupted in APP-KI mice even at a young age before the emergence of spatial memory impairments. Intriguingly, long-duration SWRs critical for memory consolidation were mildly diminished in CA1, although SWR density and amplitude remained intact. Our results point to SWR incoordination in the entorhinal-hippocampal circuit as an early network symptom that precedes memory impairment in AD. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9452631/ /pubmed/36090186 http://dx.doi.org/10.3389/fnsys.2022.955178 Text en Copyright © 2022 Funane, Jun, Sutoko, Saido, Kandori and Igarashi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Funane, Tsukasa
Jun, Heechul
Sutoko, Stephanie
Saido, Takaomi C.
Kandori, Akihiko
Igarashi, Kei M.
Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease
title Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease
title_full Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease
title_fullStr Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease
title_full_unstemmed Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease
title_short Impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal CA1 of knock-in model of Alzheimer’s disease
title_sort impaired sharp-wave ripple coordination between the medial entorhinal cortex and hippocampal ca1 of knock-in model of alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452631/
https://www.ncbi.nlm.nih.gov/pubmed/36090186
http://dx.doi.org/10.3389/fnsys.2022.955178
work_keys_str_mv AT funanetsukasa impairedsharpwaveripplecoordinationbetweenthemedialentorhinalcortexandhippocampalca1ofknockinmodelofalzheimersdisease
AT junheechul impairedsharpwaveripplecoordinationbetweenthemedialentorhinalcortexandhippocampalca1ofknockinmodelofalzheimersdisease
AT sutokostephanie impairedsharpwaveripplecoordinationbetweenthemedialentorhinalcortexandhippocampalca1ofknockinmodelofalzheimersdisease
AT saidotakaomic impairedsharpwaveripplecoordinationbetweenthemedialentorhinalcortexandhippocampalca1ofknockinmodelofalzheimersdisease
AT kandoriakihiko impairedsharpwaveripplecoordinationbetweenthemedialentorhinalcortexandhippocampalca1ofknockinmodelofalzheimersdisease
AT igarashikeim impairedsharpwaveripplecoordinationbetweenthemedialentorhinalcortexandhippocampalca1ofknockinmodelofalzheimersdisease