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LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma

Lung adenocarcinoma (LUAD) is one of the main causes of cancer-related mortality, with a strong tendency to metastasize early. Transforming growth factor-β (TGF-β) signaling is a powerful regulator to promote metastasis of LUAD. Here, we screened long non-coding RNAs (lncRNAs) responsive to TGF-β an...

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Autores principales: Xu, Wei, Chen, Linna, Liu, Jiheng, Zhang, Zhezhe, Wang, Ranran, Zhang, Qianqian, Li, Huiting, Xiang, Juanjuan, Fang, Li, Xu, Ping, Li, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452677/
https://www.ncbi.nlm.nih.gov/pubmed/36071042
http://dx.doi.org/10.1038/s41419-022-05164-2
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author Xu, Wei
Chen, Linna
Liu, Jiheng
Zhang, Zhezhe
Wang, Ranran
Zhang, Qianqian
Li, Huiting
Xiang, Juanjuan
Fang, Li
Xu, Ping
Li, Zheng
author_facet Xu, Wei
Chen, Linna
Liu, Jiheng
Zhang, Zhezhe
Wang, Ranran
Zhang, Qianqian
Li, Huiting
Xiang, Juanjuan
Fang, Li
Xu, Ping
Li, Zheng
author_sort Xu, Wei
collection PubMed
description Lung adenocarcinoma (LUAD) is one of the main causes of cancer-related mortality, with a strong tendency to metastasize early. Transforming growth factor-β (TGF-β) signaling is a powerful regulator to promote metastasis of LUAD. Here, we screened long non-coding RNAs (lncRNAs) responsive to TGF-β and highly expressed in LUAD cells, and finally obtained our master molecular LINC00152. We proved that the TGF-β promoted transcription of LINC00152 through the classical TGF-β/SMAD3 signaling pathway and maintained its stability through the RNA-binding protein HuR. Moreover, LINC00152 increased ZEB1, SNAI1 and SNAI2 expression via increasing the interactions of HuR and these transcription factors, ultimately promoting epithelial-mesenchymal transition of LUAD cell and enhancing LUAD metastasis in vivo. These data provided evidence that LINC00152 induced by TGF-β promotes metastasis depending HuR in lung adenocarcinoma. Designing targeting LINC00152 and HuR inhibitors may therefore be an effective therapeutic strategy for LUAD treatment.
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spelling pubmed-94526772022-09-09 LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma Xu, Wei Chen, Linna Liu, Jiheng Zhang, Zhezhe Wang, Ranran Zhang, Qianqian Li, Huiting Xiang, Juanjuan Fang, Li Xu, Ping Li, Zheng Cell Death Dis Article Lung adenocarcinoma (LUAD) is one of the main causes of cancer-related mortality, with a strong tendency to metastasize early. Transforming growth factor-β (TGF-β) signaling is a powerful regulator to promote metastasis of LUAD. Here, we screened long non-coding RNAs (lncRNAs) responsive to TGF-β and highly expressed in LUAD cells, and finally obtained our master molecular LINC00152. We proved that the TGF-β promoted transcription of LINC00152 through the classical TGF-β/SMAD3 signaling pathway and maintained its stability through the RNA-binding protein HuR. Moreover, LINC00152 increased ZEB1, SNAI1 and SNAI2 expression via increasing the interactions of HuR and these transcription factors, ultimately promoting epithelial-mesenchymal transition of LUAD cell and enhancing LUAD metastasis in vivo. These data provided evidence that LINC00152 induced by TGF-β promotes metastasis depending HuR in lung adenocarcinoma. Designing targeting LINC00152 and HuR inhibitors may therefore be an effective therapeutic strategy for LUAD treatment. Nature Publishing Group UK 2022-09-07 /pmc/articles/PMC9452677/ /pubmed/36071042 http://dx.doi.org/10.1038/s41419-022-05164-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Xu, Wei
Chen, Linna
Liu, Jiheng
Zhang, Zhezhe
Wang, Ranran
Zhang, Qianqian
Li, Huiting
Xiang, Juanjuan
Fang, Li
Xu, Ping
Li, Zheng
LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
title LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
title_full LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
title_fullStr LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
title_full_unstemmed LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
title_short LINC00152 induced by TGF-β promotes metastasis via HuR in lung adenocarcinoma
title_sort linc00152 induced by tgf-β promotes metastasis via hur in lung adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452677/
https://www.ncbi.nlm.nih.gov/pubmed/36071042
http://dx.doi.org/10.1038/s41419-022-05164-2
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