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Extracellular traps and the role in thrombosis

Thrombotic complications pose serious health risks worldwide. A significant change in our understanding of the pathophysiology of thrombosis has occurred since the discovery of extracellular traps (ETs) and their prothrombotic properties. As a result of immune cells decondensing chromatin into extra...

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Autores principales: Han, Tonglei, Tang, Hanfei, Lin, Changpo, Shen, Yang, Yan, Dong, Tang, Xiao, Guo, Daqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452724/
https://www.ncbi.nlm.nih.gov/pubmed/36093130
http://dx.doi.org/10.3389/fcvm.2022.951670
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author Han, Tonglei
Tang, Hanfei
Lin, Changpo
Shen, Yang
Yan, Dong
Tang, Xiao
Guo, Daqiao
author_facet Han, Tonglei
Tang, Hanfei
Lin, Changpo
Shen, Yang
Yan, Dong
Tang, Xiao
Guo, Daqiao
author_sort Han, Tonglei
collection PubMed
description Thrombotic complications pose serious health risks worldwide. A significant change in our understanding of the pathophysiology of thrombosis has occurred since the discovery of extracellular traps (ETs) and their prothrombotic properties. As a result of immune cells decondensing chromatin into extracellular fibers, ETs promote thrombus formation by acting as a scaffold that activates platelets and coagulates them. The involvement of ETs in thrombosis has been reported in various thrombotic conditions including deep vein thrombosis (DVT), pulmonary emboli, acute myocardial infarction, aucte ischemic stroke, and abdominal aortic aneurysms. This review summarizes the existing evidence of ETs in human and animal model thrombi. The authors described studies showing the existence of ETs in venous or arterial thrombi. In addition, we studied potential novel therapeutic opportunities related to the resolution or prevention of thrombosis by targeting ETs.
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spelling pubmed-94527242022-09-09 Extracellular traps and the role in thrombosis Han, Tonglei Tang, Hanfei Lin, Changpo Shen, Yang Yan, Dong Tang, Xiao Guo, Daqiao Front Cardiovasc Med Cardiovascular Medicine Thrombotic complications pose serious health risks worldwide. A significant change in our understanding of the pathophysiology of thrombosis has occurred since the discovery of extracellular traps (ETs) and their prothrombotic properties. As a result of immune cells decondensing chromatin into extracellular fibers, ETs promote thrombus formation by acting as a scaffold that activates platelets and coagulates them. The involvement of ETs in thrombosis has been reported in various thrombotic conditions including deep vein thrombosis (DVT), pulmonary emboli, acute myocardial infarction, aucte ischemic stroke, and abdominal aortic aneurysms. This review summarizes the existing evidence of ETs in human and animal model thrombi. The authors described studies showing the existence of ETs in venous or arterial thrombi. In addition, we studied potential novel therapeutic opportunities related to the resolution or prevention of thrombosis by targeting ETs. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9452724/ /pubmed/36093130 http://dx.doi.org/10.3389/fcvm.2022.951670 Text en Copyright © 2022 Han, Tang, Lin, Shen, Yan, Tang and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Han, Tonglei
Tang, Hanfei
Lin, Changpo
Shen, Yang
Yan, Dong
Tang, Xiao
Guo, Daqiao
Extracellular traps and the role in thrombosis
title Extracellular traps and the role in thrombosis
title_full Extracellular traps and the role in thrombosis
title_fullStr Extracellular traps and the role in thrombosis
title_full_unstemmed Extracellular traps and the role in thrombosis
title_short Extracellular traps and the role in thrombosis
title_sort extracellular traps and the role in thrombosis
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452724/
https://www.ncbi.nlm.nih.gov/pubmed/36093130
http://dx.doi.org/10.3389/fcvm.2022.951670
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