Strategies to safely target widely expressed soluble adenylyl cyclase for contraception

In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY1...

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Detalles Bibliográficos
Autores principales: Ferreira, Jacob, Levin, Lonny R., Buck, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452739/
https://www.ncbi.nlm.nih.gov/pubmed/36091839
http://dx.doi.org/10.3389/fphar.2022.953903
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author Ferreira, Jacob
Levin, Lonny R.
Buck, Jochen
author_facet Ferreira, Jacob
Levin, Lonny R.
Buck, Jochen
author_sort Ferreira, Jacob
collection PubMed
description In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception.
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spelling pubmed-94527392022-09-09 Strategies to safely target widely expressed soluble adenylyl cyclase for contraception Ferreira, Jacob Levin, Lonny R. Buck, Jochen Front Pharmacol Pharmacology In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate regulated soluble adenylyl cyclase (sAC; ADCY10). This review details why sAC is uniquely druggable and outlines ways to target sAC for novel forms of male and female contraception. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9452739/ /pubmed/36091839 http://dx.doi.org/10.3389/fphar.2022.953903 Text en Copyright © 2022 Ferreira, Levin and Buck. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ferreira, Jacob
Levin, Lonny R.
Buck, Jochen
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
title Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
title_full Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
title_fullStr Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
title_full_unstemmed Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
title_short Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
title_sort strategies to safely target widely expressed soluble adenylyl cyclase for contraception
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452739/
https://www.ncbi.nlm.nih.gov/pubmed/36091839
http://dx.doi.org/10.3389/fphar.2022.953903
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