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Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation

Infantile amnesia, the inability to form long-lasting episodic memories, is a phenomenon extensively known but with no clear understanding of its origins. However, a recent study showed that high rates of hippocampal postnatal neurogenesis degrade episodic-like memories in infants a few days after m...

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Autores principales: López-Oropeza, Grecia, Durán, Pilar, Martínez-Canabal, Alonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452746/
https://www.ncbi.nlm.nih.gov/pubmed/36090654
http://dx.doi.org/10.3389/fnbeh.2022.971359
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author López-Oropeza, Grecia
Durán, Pilar
Martínez-Canabal, Alonso
author_facet López-Oropeza, Grecia
Durán, Pilar
Martínez-Canabal, Alonso
author_sort López-Oropeza, Grecia
collection PubMed
description Infantile amnesia, the inability to form long-lasting episodic memories, is a phenomenon extensively known but with no clear understanding of its origins. However, a recent study showed that high rates of hippocampal postnatal neurogenesis degrade episodic-like memories in infants a few days after memory acquisition. Additionally, new studies indicate that exposure to an enriched environment in mice leads to high hippocampal neurogenesis in their offspring. Nevertheless, it is still unclear how this intergenerational trait affects the persistence of hippocampal memories. Therefore, we evaluated spatial memory retention in the offspring of enriched female mice after weaning to address this question. Ten days after spatial learning, we tested memory retention, observing that the offspring of enriched dams increased spatial memory failure; this finding correlates with high proliferation rates in the hippocampus. Furthermore, we evaluated the causal relationship between postnatal hippocampal neurogenesis and memory failure using the antiproliferative drug Temozolomide (TMZ), which rescued spatial memory retrieval. Finally, we evaluated neuronal activity in the hippocampus quantifying the cells expressing the immediate early gene c-Fos. This evaluation showed engram modifications between groups. This neural activity pattern indicates that the high neurogenesis rates can modify memory engrams and cognitive performance. In conclusion, the inherited increase of hippocampal neurogenesis by enriched dams leads to plastic changes that exacerbate infantile amnesia in a spatial task.
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spelling pubmed-94527462022-09-09 Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation López-Oropeza, Grecia Durán, Pilar Martínez-Canabal, Alonso Front Behav Neurosci Behavioral Neuroscience Infantile amnesia, the inability to form long-lasting episodic memories, is a phenomenon extensively known but with no clear understanding of its origins. However, a recent study showed that high rates of hippocampal postnatal neurogenesis degrade episodic-like memories in infants a few days after memory acquisition. Additionally, new studies indicate that exposure to an enriched environment in mice leads to high hippocampal neurogenesis in their offspring. Nevertheless, it is still unclear how this intergenerational trait affects the persistence of hippocampal memories. Therefore, we evaluated spatial memory retention in the offspring of enriched female mice after weaning to address this question. Ten days after spatial learning, we tested memory retention, observing that the offspring of enriched dams increased spatial memory failure; this finding correlates with high proliferation rates in the hippocampus. Furthermore, we evaluated the causal relationship between postnatal hippocampal neurogenesis and memory failure using the antiproliferative drug Temozolomide (TMZ), which rescued spatial memory retrieval. Finally, we evaluated neuronal activity in the hippocampus quantifying the cells expressing the immediate early gene c-Fos. This evaluation showed engram modifications between groups. This neural activity pattern indicates that the high neurogenesis rates can modify memory engrams and cognitive performance. In conclusion, the inherited increase of hippocampal neurogenesis by enriched dams leads to plastic changes that exacerbate infantile amnesia in a spatial task. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9452746/ /pubmed/36090654 http://dx.doi.org/10.3389/fnbeh.2022.971359 Text en Copyright © 2022 López-Oropeza, Durán and Martínez-Canabal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
López-Oropeza, Grecia
Durán, Pilar
Martínez-Canabal, Alonso
Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
title Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
title_full Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
title_fullStr Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
title_full_unstemmed Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
title_short Maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
title_sort maternal enrichment increases infantile spatial amnesia mediated by postnatal neurogenesis modulation
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452746/
https://www.ncbi.nlm.nih.gov/pubmed/36090654
http://dx.doi.org/10.3389/fnbeh.2022.971359
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