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Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females
BACKGROUND: Primary breast lymphoma (PBL) is a rare disease condition and is mainly observed in females. No male PBL cohorts were reported previously. This study aims to investigate the incidence, clinical characteristics, prognostic factors, and survival outcomes among male PBL patients and also to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452836/ https://www.ncbi.nlm.nih.gov/pubmed/36090327 http://dx.doi.org/10.3389/fsurg.2022.984497 |
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author | Zhang, Jie Ma, Binbin Ji, Hong Guo, Rong |
author_facet | Zhang, Jie Ma, Binbin Ji, Hong Guo, Rong |
author_sort | Zhang, Jie |
collection | PubMed |
description | BACKGROUND: Primary breast lymphoma (PBL) is a rare disease condition and is mainly observed in females. No male PBL cohorts were reported previously. This study aims to investigate the incidence, clinical characteristics, prognostic factors, and survival outcomes among male PBL patients and also to perform comparisons between males and females. METHODS: Patients diagnosed with PBL between 2000 and 2019 from the Surveillance, Epidemiology, and End Results (SEER) database were identified. Age-adjusted incidence rates were calculated by year and age for trend analysis. Univariate and multivariate Cox hazard proportional regression analyses were performed to identify prognostic factors. Survival comparisons were conducted using the Kaplan–Meier method and the log-rank test. The propensity matching score (PSM) method was used to balance demographics. RESULTS: The incidence rate of 122 male PBL patients diagnosed in the period of 2000 to 2019 was 0.169 (95% CI: 0.140–2.203) per million persons, which was much lower than that of 2,543 females (1.59, 95% CI: 1.53–1.65). Clinical demographics were similar between females and males, except for lymphoma subtype distribution (P = 0.025). A higher age [hazard ratio (HR) = 1.08, 95% CI: 1.05–1.12, P < 0.001] and not receiving radiotherapy (receiving vs. not receiving: HR = 0.41, 95% CI: 0.21–0.78, P = 0.007) were significant risk factors associated with overall survival (OS) in males. Radiotherapy (OS: P = 0.023) can offer benefits in OS. Using the PSM method, we also revealed that male PBL patients had significantly worse OS and cancer-specific survival rates than females. CONCLUSIONS: This study first analyzed male patients with PBL involving incidence, clinical characteristics, and survival data. Sex disparity was also observed in the survival outcome of the disease. |
format | Online Article Text |
id | pubmed-9452836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94528362022-09-09 Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females Zhang, Jie Ma, Binbin Ji, Hong Guo, Rong Front Surg Surgery BACKGROUND: Primary breast lymphoma (PBL) is a rare disease condition and is mainly observed in females. No male PBL cohorts were reported previously. This study aims to investigate the incidence, clinical characteristics, prognostic factors, and survival outcomes among male PBL patients and also to perform comparisons between males and females. METHODS: Patients diagnosed with PBL between 2000 and 2019 from the Surveillance, Epidemiology, and End Results (SEER) database were identified. Age-adjusted incidence rates were calculated by year and age for trend analysis. Univariate and multivariate Cox hazard proportional regression analyses were performed to identify prognostic factors. Survival comparisons were conducted using the Kaplan–Meier method and the log-rank test. The propensity matching score (PSM) method was used to balance demographics. RESULTS: The incidence rate of 122 male PBL patients diagnosed in the period of 2000 to 2019 was 0.169 (95% CI: 0.140–2.203) per million persons, which was much lower than that of 2,543 females (1.59, 95% CI: 1.53–1.65). Clinical demographics were similar between females and males, except for lymphoma subtype distribution (P = 0.025). A higher age [hazard ratio (HR) = 1.08, 95% CI: 1.05–1.12, P < 0.001] and not receiving radiotherapy (receiving vs. not receiving: HR = 0.41, 95% CI: 0.21–0.78, P = 0.007) were significant risk factors associated with overall survival (OS) in males. Radiotherapy (OS: P = 0.023) can offer benefits in OS. Using the PSM method, we also revealed that male PBL patients had significantly worse OS and cancer-specific survival rates than females. CONCLUSIONS: This study first analyzed male patients with PBL involving incidence, clinical characteristics, and survival data. Sex disparity was also observed in the survival outcome of the disease. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9452836/ /pubmed/36090327 http://dx.doi.org/10.3389/fsurg.2022.984497 Text en © 2022 Zhang, Ma, Ji and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Zhang, Jie Ma, Binbin Ji, Hong Guo, Rong Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females |
title | Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females |
title_full | Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females |
title_fullStr | Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females |
title_full_unstemmed | Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females |
title_short | Primary breast lymphoma in males: Incidence, demographics, prognostic factors, survival, and comparisons with females |
title_sort | primary breast lymphoma in males: incidence, demographics, prognostic factors, survival, and comparisons with females |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452836/ https://www.ncbi.nlm.nih.gov/pubmed/36090327 http://dx.doi.org/10.3389/fsurg.2022.984497 |
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