A Wars2 mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning

Background: Increased waist-to-hip ratio (WHR) is associated with increased mortality and risk of type 2 diabetes and cardiovascular disease. The TBX15-WARS2 locus has consistently been associated with increased WHR. Previous study of the hypomorphic Wars2 ( V117L/V117L ) mouse model found phenotype...

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Detalles Bibliográficos
Autores principales: Mušo, Milan, Bentley, Liz, Vizor, Lucie, Yon, Marianne, Burling, Keith, Barker, Peter, Zolkiewski, Louisa A. K., Cox, Roger D., Dumbell, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452902/
https://www.ncbi.nlm.nih.gov/pubmed/36091365
http://dx.doi.org/10.3389/fphys.2022.953199

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