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Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments

Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activi...

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Autores principales: Enayati, Ayesheh, Ghojoghnejad, Mobina, Roufogalis, Basil D., Maollem, Seyed Adel, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453090/
https://www.ncbi.nlm.nih.gov/pubmed/36092543
http://dx.doi.org/10.1155/2022/4714914
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author Enayati, Ayesheh
Ghojoghnejad, Mobina
Roufogalis, Basil D.
Maollem, Seyed Adel
Sahebkar, Amirhossein
author_facet Enayati, Ayesheh
Ghojoghnejad, Mobina
Roufogalis, Basil D.
Maollem, Seyed Adel
Sahebkar, Amirhossein
author_sort Enayati, Ayesheh
collection PubMed
description Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activities and multiple organ toxicity, including cellular differentiation, metabolic syndrome, cancer, atherosclerosis, neurodegeneration, cardiovascular diseases, and inflammation related to their up/downstream signaling pathways. Consequently, several types of selective PPAR ligands, such as fibrates and thiazolidinediones (TZDs), have been approved as their pharmacological agonists. Despite these advances, the use of PPAR agonists is known to cause adverse effects in various systems. Conversely, some naturally occurring PPAR agonists, including polyunsaturated fatty acids and natural endogenous PPAR agonists curcumin and resveratrol, have been introduced as safe agonists as a result of their clinical evidence or preclinical experiments. This review focuses on research on plant-derived active ingredients (natural phytochemicals) as potential safe and promising PPAR agonists. Moreover, it provides a comprehensive review and critique of the role of phytochemicals in PPARs-related diseases and provides an understanding of phytochemical-mediated PPAR-dependent and -independent cascades. The findings of this research will help to define the functions of phytochemicals as potent PPAR pharmacological agonists in underlying disease mechanisms and their related complications.
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spelling pubmed-94530902022-09-09 Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments Enayati, Ayesheh Ghojoghnejad, Mobina Roufogalis, Basil D. Maollem, Seyed Adel Sahebkar, Amirhossein PPAR Res Review Article Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activities and multiple organ toxicity, including cellular differentiation, metabolic syndrome, cancer, atherosclerosis, neurodegeneration, cardiovascular diseases, and inflammation related to their up/downstream signaling pathways. Consequently, several types of selective PPAR ligands, such as fibrates and thiazolidinediones (TZDs), have been approved as their pharmacological agonists. Despite these advances, the use of PPAR agonists is known to cause adverse effects in various systems. Conversely, some naturally occurring PPAR agonists, including polyunsaturated fatty acids and natural endogenous PPAR agonists curcumin and resveratrol, have been introduced as safe agonists as a result of their clinical evidence or preclinical experiments. This review focuses on research on plant-derived active ingredients (natural phytochemicals) as potential safe and promising PPAR agonists. Moreover, it provides a comprehensive review and critique of the role of phytochemicals in PPARs-related diseases and provides an understanding of phytochemical-mediated PPAR-dependent and -independent cascades. The findings of this research will help to define the functions of phytochemicals as potent PPAR pharmacological agonists in underlying disease mechanisms and their related complications. Hindawi 2022-08-31 /pmc/articles/PMC9453090/ /pubmed/36092543 http://dx.doi.org/10.1155/2022/4714914 Text en Copyright © 2022 Ayesheh Enayati et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Enayati, Ayesheh
Ghojoghnejad, Mobina
Roufogalis, Basil D.
Maollem, Seyed Adel
Sahebkar, Amirhossein
Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments
title Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments
title_full Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments
title_fullStr Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments
title_full_unstemmed Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments
title_short Impact of Phytochemicals on PPAR Receptors: Implications for Disease Treatments
title_sort impact of phytochemicals on ppar receptors: implications for disease treatments
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453090/
https://www.ncbi.nlm.nih.gov/pubmed/36092543
http://dx.doi.org/10.1155/2022/4714914
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