A Fe(2+)-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes

Multifunctional human collagen lysyl hydroxylase (LH/PLOD) enzymes catalyze post-translational hydroxylation and subsequent glycosylation of collagens, enabling their maturation and supramolecular organization in the extracellular matrix (ECM). Recently, the overexpression of LH/PLODs in the tumor m...

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Detalles Bibliográficos
Autores principales: Scietti, Luigi, Moroni, Elisabetta, Mattoteia, Daiana, Fumagalli, Marco, De Marco, Matteo, Negro, Lisa, Chiapparino, Antonella, Serapian, Stefano A., De Giorgi, Francesca, Faravelli, Silvia, Colombo, Giorgio, Forneris, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453210/
https://www.ncbi.nlm.nih.gov/pubmed/36090047
http://dx.doi.org/10.3389/fmolb.2022.876352

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