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Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood

Sleep plays a key role in supporting brain function and resilience to brain decline. It is well known that sleep changes substantially with aging and that aging is associated with deterioration of brain structure. In this study, we sought to characterize the relationship between slow wave slope (SWs...

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Autores principales: Gudberg, Christel, Stevelink, Remi, Douaud, Gwenaëlle, Wulff, Katharina, Lazari, Alberto, Fleming, Melanie K., Johansen-Berg, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453235/
https://www.ncbi.nlm.nih.gov/pubmed/36092806
http://dx.doi.org/10.3389/fnagi.2022.745014
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author Gudberg, Christel
Stevelink, Remi
Douaud, Gwenaëlle
Wulff, Katharina
Lazari, Alberto
Fleming, Melanie K.
Johansen-Berg, Heidi
author_facet Gudberg, Christel
Stevelink, Remi
Douaud, Gwenaëlle
Wulff, Katharina
Lazari, Alberto
Fleming, Melanie K.
Johansen-Berg, Heidi
author_sort Gudberg, Christel
collection PubMed
description Sleep plays a key role in supporting brain function and resilience to brain decline. It is well known that sleep changes substantially with aging and that aging is associated with deterioration of brain structure. In this study, we sought to characterize the relationship between slow wave slope (SWslope)—a key marker of sleep architecture and an indirect proxy of sleep quality—and microstructure of white matter pathways in healthy adults with no sleep complaints. Participants were 12 young (24–27 years) and 12 older (50–79 years) adults. Sleep was assessed with nocturnal electroencephalography (EEG) and the Pittsburgh Sleep Quality Index (PSQI). White matter integrity was assessed using tract-based spatial statistics (TBSS) on tensor-based metrics such as Fractional Anisotropy (FA) and Mean Diffusivity (MD). Global PSQI score did not differ between younger (n = 11) and older (n = 11) adults (U = 50, p = 0.505), but EEG revealed that younger adults had a steeper SWslope at both frontal electrode sites (F3: U = 2, p < 0.001, F4: U = 4, p < 0.001, n = 12 younger, 10 older). There were widespread correlations between various diffusion tensor-based metrics of white matter integrity and sleep SWslope, over and above effects of age (n = 11 younger, 9 older). This was particularly evident for the corpus callosum, corona radiata, superior longitudinal fasciculus, internal and external capsule. This indicates that reduced sleep slow waves may be associated with widespread white matter deterioration. Future studies should investigate whether interventions targeted at improving sleep architecture also impact on decline in white matter microstructure in older adults.
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spelling pubmed-94532352022-09-09 Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood Gudberg, Christel Stevelink, Remi Douaud, Gwenaëlle Wulff, Katharina Lazari, Alberto Fleming, Melanie K. Johansen-Berg, Heidi Front Aging Neurosci Aging Neuroscience Sleep plays a key role in supporting brain function and resilience to brain decline. It is well known that sleep changes substantially with aging and that aging is associated with deterioration of brain structure. In this study, we sought to characterize the relationship between slow wave slope (SWslope)—a key marker of sleep architecture and an indirect proxy of sleep quality—and microstructure of white matter pathways in healthy adults with no sleep complaints. Participants were 12 young (24–27 years) and 12 older (50–79 years) adults. Sleep was assessed with nocturnal electroencephalography (EEG) and the Pittsburgh Sleep Quality Index (PSQI). White matter integrity was assessed using tract-based spatial statistics (TBSS) on tensor-based metrics such as Fractional Anisotropy (FA) and Mean Diffusivity (MD). Global PSQI score did not differ between younger (n = 11) and older (n = 11) adults (U = 50, p = 0.505), but EEG revealed that younger adults had a steeper SWslope at both frontal electrode sites (F3: U = 2, p < 0.001, F4: U = 4, p < 0.001, n = 12 younger, 10 older). There were widespread correlations between various diffusion tensor-based metrics of white matter integrity and sleep SWslope, over and above effects of age (n = 11 younger, 9 older). This was particularly evident for the corpus callosum, corona radiata, superior longitudinal fasciculus, internal and external capsule. This indicates that reduced sleep slow waves may be associated with widespread white matter deterioration. Future studies should investigate whether interventions targeted at improving sleep architecture also impact on decline in white matter microstructure in older adults. Frontiers Media S.A. 2022-08-25 /pmc/articles/PMC9453235/ /pubmed/36092806 http://dx.doi.org/10.3389/fnagi.2022.745014 Text en Copyright © 2022 Gudberg, Stevelink, Douaud, Wulff, Lazari, Fleming and Johansen-Berg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Gudberg, Christel
Stevelink, Remi
Douaud, Gwenaëlle
Wulff, Katharina
Lazari, Alberto
Fleming, Melanie K.
Johansen-Berg, Heidi
Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
title Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
title_full Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
title_fullStr Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
title_full_unstemmed Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
title_short Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
title_sort individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453235/
https://www.ncbi.nlm.nih.gov/pubmed/36092806
http://dx.doi.org/10.3389/fnagi.2022.745014
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