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Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells

Exogenous glucocorticoids increase the risk for osteoporosis, but the role of endogenous glucocorticoids remains elusive. Here, we describe the generation and validation of a loss- and a gain-of-function model of the cortisol producing enzyme 11β-HSD1 (HSD11B1) to modulate the endogenous glucocortic...

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Detalles Bibliográficos
Autores principales:	Kragl, Angelique, Schoon, Janosch, Tzvetkova, Ana, Wenzel, Christoph, Blaschke, Martina, Böcker, Wolfgang, Siggelkow, Heide, Tzvetkov, Mladen V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453430/ https://www.ncbi.nlm.nih.gov/pubmed/36091434 http://dx.doi.org/10.3389/fbioe.2022.953034

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