Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia

AIM: This study aimed to identify patient characteristics, treatment patterns and outcomes and to evaluate the effects of presence of comorbidities at diagnosis in chronic phase (CP)-chronic myeloid leukemia (CML) patients in Turkey. MATERIALS & METHODS: Hospital records between 2005 and 2018 we...

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Autores principales: Saydam, Guray, Unal, Ali, Haznedaroglu, Ibrahim Celalettin, Hacihanifioglu, Abdullah, Mehtap, Ozgur, Kurtoglu, Erdal, Gocer, Mesut, Turgut, Mehmet, Kelkitli, Engin, Atay, Memis Hilmi, Guler, Nil, Koluman, Basak Unver, Sonmez, Mehmet, Erkut, Nergiz, Kaya, Emin, Kuku, Irfan, Erkurt, Mehmet Ali, Ozet, Gulsum, Ceran, Funda, Sahin, Fahri, Soyer, Nur, Nalcaci, Meliha, Yilmaz, Mehmet, Bozkurt, Sirac, Aver, Birkan, Ozdengulsun, Begum, Ozbilgili, Egemen, Ilhan, Osman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453544/
https://www.ncbi.nlm.nih.gov/pubmed/36101779
http://dx.doi.org/10.2217/ijh-2021-0008
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author Saydam, Guray
Unal, Ali
Haznedaroglu, Ibrahim Celalettin
Hacihanifioglu, Abdullah
Mehtap, Ozgur
Kurtoglu, Erdal
Gocer, Mesut
Turgut, Mehmet
Kelkitli, Engin
Atay, Memis Hilmi
Guler, Nil
Koluman, Basak Unver
Sonmez, Mehmet
Erkut, Nergiz
Kaya, Emin
Kuku, Irfan
Erkurt, Mehmet Ali
Ozet, Gulsum
Ceran, Funda
Sahin, Fahri
Soyer, Nur
Nalcaci, Meliha
Yilmaz, Mehmet
Bozkurt, Sirac
Aver, Birkan
Ozdengulsun, Begum
Ozbilgili, Egemen
Ilhan, Osman
author_facet Saydam, Guray
Unal, Ali
Haznedaroglu, Ibrahim Celalettin
Hacihanifioglu, Abdullah
Mehtap, Ozgur
Kurtoglu, Erdal
Gocer, Mesut
Turgut, Mehmet
Kelkitli, Engin
Atay, Memis Hilmi
Guler, Nil
Koluman, Basak Unver
Sonmez, Mehmet
Erkut, Nergiz
Kaya, Emin
Kuku, Irfan
Erkurt, Mehmet Ali
Ozet, Gulsum
Ceran, Funda
Sahin, Fahri
Soyer, Nur
Nalcaci, Meliha
Yilmaz, Mehmet
Bozkurt, Sirac
Aver, Birkan
Ozdengulsun, Begum
Ozbilgili, Egemen
Ilhan, Osman
author_sort Saydam, Guray
collection PubMed
description AIM: This study aimed to identify patient characteristics, treatment patterns and outcomes and to evaluate the effects of presence of comorbidities at diagnosis in chronic phase (CP)-chronic myeloid leukemia (CML) patients in Turkey. MATERIALS & METHODS: Hospital records between 2005 and 2018 were retrospectively reviewed. RESULTS: Of 861 CP-CML patients included, 31% had at least one comorbidity at diagnosis. Sex, cardiovascular disease status at diagnosis and molecular (at least major) and cytogenetic (partial and complete) responses were the independent predictors of survival. CONCLUSION: The response rates of CP-CML patients to the tyrosine kinase inhibitors were satisfactory. In addition to tolerability and side effect profiles of drugs, comorbidity status of patients should also be considered in treatment choice in CML patients.
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spelling pubmed-94535442022-09-12 Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia Saydam, Guray Unal, Ali Haznedaroglu, Ibrahim Celalettin Hacihanifioglu, Abdullah Mehtap, Ozgur Kurtoglu, Erdal Gocer, Mesut Turgut, Mehmet Kelkitli, Engin Atay, Memis Hilmi Guler, Nil Koluman, Basak Unver Sonmez, Mehmet Erkut, Nergiz Kaya, Emin Kuku, Irfan Erkurt, Mehmet Ali Ozet, Gulsum Ceran, Funda Sahin, Fahri Soyer, Nur Nalcaci, Meliha Yilmaz, Mehmet Bozkurt, Sirac Aver, Birkan Ozdengulsun, Begum Ozbilgili, Egemen Ilhan, Osman Int J Hematol Oncol Research Article AIM: This study aimed to identify patient characteristics, treatment patterns and outcomes and to evaluate the effects of presence of comorbidities at diagnosis in chronic phase (CP)-chronic myeloid leukemia (CML) patients in Turkey. MATERIALS & METHODS: Hospital records between 2005 and 2018 were retrospectively reviewed. RESULTS: Of 861 CP-CML patients included, 31% had at least one comorbidity at diagnosis. Sex, cardiovascular disease status at diagnosis and molecular (at least major) and cytogenetic (partial and complete) responses were the independent predictors of survival. CONCLUSION: The response rates of CP-CML patients to the tyrosine kinase inhibitors were satisfactory. In addition to tolerability and side effect profiles of drugs, comorbidity status of patients should also be considered in treatment choice in CML patients. Future Medicine Ltd 2022-06-30 /pmc/articles/PMC9453544/ /pubmed/36101779 http://dx.doi.org/10.2217/ijh-2021-0008 Text en © 2022 Guray Saydam https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Research Article
Saydam, Guray
Unal, Ali
Haznedaroglu, Ibrahim Celalettin
Hacihanifioglu, Abdullah
Mehtap, Ozgur
Kurtoglu, Erdal
Gocer, Mesut
Turgut, Mehmet
Kelkitli, Engin
Atay, Memis Hilmi
Guler, Nil
Koluman, Basak Unver
Sonmez, Mehmet
Erkut, Nergiz
Kaya, Emin
Kuku, Irfan
Erkurt, Mehmet Ali
Ozet, Gulsum
Ceran, Funda
Sahin, Fahri
Soyer, Nur
Nalcaci, Meliha
Yilmaz, Mehmet
Bozkurt, Sirac
Aver, Birkan
Ozdengulsun, Begum
Ozbilgili, Egemen
Ilhan, Osman
Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia
title Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia
title_full Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia
title_fullStr Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia
title_full_unstemmed Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia
title_short Turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia
title_sort turkey real-life data: demographic features, treatment results and effects of comorbidities in chronic myeloid leukemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453544/
https://www.ncbi.nlm.nih.gov/pubmed/36101779
http://dx.doi.org/10.2217/ijh-2021-0008
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