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Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics

Slow waves, the hallmark feature of deep nonrapid eye movement sleep, do potentially drive restorative effects of sleep on brain and body functions. Sleep modulation techniques to elucidate the functional role of slow waves thus have gained large interest. Auditory slow wave stimulation is a promisi...

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Autores principales: Huwiler, Stephanie, Carro Dominguez, Manuel, Huwyler, Silja, Kiener, Luca, Stich, Fabia M, Sala, Rossella, Aziri, Florent, Trippel, Anna, Schmied, Christian, Huber, Reto, Wenderoth, Nicole, Lustenberger, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453626/
https://www.ncbi.nlm.nih.gov/pubmed/35793672
http://dx.doi.org/10.1093/sleep/zsac155
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author Huwiler, Stephanie
Carro Dominguez, Manuel
Huwyler, Silja
Kiener, Luca
Stich, Fabia M
Sala, Rossella
Aziri, Florent
Trippel, Anna
Schmied, Christian
Huber, Reto
Wenderoth, Nicole
Lustenberger, Caroline
author_facet Huwiler, Stephanie
Carro Dominguez, Manuel
Huwyler, Silja
Kiener, Luca
Stich, Fabia M
Sala, Rossella
Aziri, Florent
Trippel, Anna
Schmied, Christian
Huber, Reto
Wenderoth, Nicole
Lustenberger, Caroline
author_sort Huwiler, Stephanie
collection PubMed
description Slow waves, the hallmark feature of deep nonrapid eye movement sleep, do potentially drive restorative effects of sleep on brain and body functions. Sleep modulation techniques to elucidate the functional role of slow waves thus have gained large interest. Auditory slow wave stimulation is a promising tool; however, directly comparing auditory stimulation approaches within a night and analyzing induced dynamic brain and cardiovascular effects are yet missing. Here, we tested various auditory stimulation approaches in a windowed, 10 s ON (stimulations) followed by 10 s OFF (no stimulations), within-night stimulation design and compared them to a SHAM control condition. We report the results of three studies and a total of 51 included nights and found a large and global increase in slow-wave activity (SWA) in the stimulation window compared to SHAM. Furthermore, slow-wave dynamics were most pronouncedly increased at the start of the stimulation and declined across the stimulation window. Beyond the changes in brain oscillations, we observed, for some conditions, a significant increase in the mean interval between two heartbeats within a stimulation window, indicating a slowing of the heart rate, and increased heart rate variability derived parasympathetic activity. Those cardiovascular changes were positively correlated with the change in SWA, and thus, our findings provide insight into the potential of auditory slow wave enhancement to modulate cardiovascular restorative conditions during sleep. However, future studies need to investigate whether the potentially increased restorative capacity through slow-wave enhancements translates into a more rested cardiovascular system on a subsequent day.
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spelling pubmed-94536262022-09-09 Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics Huwiler, Stephanie Carro Dominguez, Manuel Huwyler, Silja Kiener, Luca Stich, Fabia M Sala, Rossella Aziri, Florent Trippel, Anna Schmied, Christian Huber, Reto Wenderoth, Nicole Lustenberger, Caroline Sleep Basic Science of Sleep and Circadian Rhythms Slow waves, the hallmark feature of deep nonrapid eye movement sleep, do potentially drive restorative effects of sleep on brain and body functions. Sleep modulation techniques to elucidate the functional role of slow waves thus have gained large interest. Auditory slow wave stimulation is a promising tool; however, directly comparing auditory stimulation approaches within a night and analyzing induced dynamic brain and cardiovascular effects are yet missing. Here, we tested various auditory stimulation approaches in a windowed, 10 s ON (stimulations) followed by 10 s OFF (no stimulations), within-night stimulation design and compared them to a SHAM control condition. We report the results of three studies and a total of 51 included nights and found a large and global increase in slow-wave activity (SWA) in the stimulation window compared to SHAM. Furthermore, slow-wave dynamics were most pronouncedly increased at the start of the stimulation and declined across the stimulation window. Beyond the changes in brain oscillations, we observed, for some conditions, a significant increase in the mean interval between two heartbeats within a stimulation window, indicating a slowing of the heart rate, and increased heart rate variability derived parasympathetic activity. Those cardiovascular changes were positively correlated with the change in SWA, and thus, our findings provide insight into the potential of auditory slow wave enhancement to modulate cardiovascular restorative conditions during sleep. However, future studies need to investigate whether the potentially increased restorative capacity through slow-wave enhancements translates into a more rested cardiovascular system on a subsequent day. Oxford University Press 2022-07-06 /pmc/articles/PMC9453626/ /pubmed/35793672 http://dx.doi.org/10.1093/sleep/zsac155 Text en © Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Science of Sleep and Circadian Rhythms
Huwiler, Stephanie
Carro Dominguez, Manuel
Huwyler, Silja
Kiener, Luca
Stich, Fabia M
Sala, Rossella
Aziri, Florent
Trippel, Anna
Schmied, Christian
Huber, Reto
Wenderoth, Nicole
Lustenberger, Caroline
Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics
title Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics
title_full Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics
title_fullStr Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics
title_full_unstemmed Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics
title_short Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics
title_sort effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics
topic Basic Science of Sleep and Circadian Rhythms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453626/
https://www.ncbi.nlm.nih.gov/pubmed/35793672
http://dx.doi.org/10.1093/sleep/zsac155
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